DEVELOPMENTAL DYSLEXIA IN WOMEN - NEUROPATHOLOGICAL FINDINGS IN 3 PATIENTS
DEVELOPMENTAL DYSLEXIA IN WOMEN - NEUROPATHOLOGICAL FINDINGS IN 3 PATIENTS
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DOI：
10.1002/ana.410280602
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发表时间：
1990-12-01
影响因子：
11.2
通讯作者：
GALABURDA, AM
中科院分区：
文献类型：
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作者：
HUMPHREYS, P;KAUFMANN, WE;GALABURDA, AM
男性失读症患者的大脑表现为颞平面对称，以左侧脑皮质微发育不良为主。我们现在报道三名患有阅读障碍的女性。所有大脑的颞平面都是对称的。另外，在两个大脑中，存在多灶脑皮质胶质瘢痕。在这两名女性中，许多疤痕都是有髓鞘的，表明是在宫内晚期或出生后早期形成的。在一名女性中，疤痕主要是在外围留下的，并累及了颞叶皮层的部分血管边界区。另一组瘢痕较多，呈对称分布于大脑前、中、后动脉交界区。所有三例均表现出不同程度的脑疣、分子层异位和局灶性结构发育不良，与男性病例相同。两名女性分别患有原发性脑肿瘤，少突胶质细胞瘤和低度星形细胞瘤，两名女性表现为小血管瘤。对先前报告的男性病例复查发现一例有髓鞘胶质瘢痕。两个颞平面不对称的对照脑也显示髓鞘胶质瘢痕。讨论了解剖结果的意义，并考虑了可能的病因因素与已知的自身免疫性疾病对神经系统的影响。
Brains from male cases with dyslexia show symmetry of the planum temporale and predominantly left-sided cerebrocortical microdysgenesis. We now report on three women with dyslexia. In all brains, the planum temporale was again symmetrical. Also, in two of the brains, multiple foci of cerebrocortical glial scarring were present. In both women, many of the scars were myelinated, suggesting originating during late intrauterine or early postnatal life, In one, scars were mainly left perisylvian and involved portions of the vascular border zone of the temporal cortex. In the other, scars were more numerous and occurred in the border zone of the anterior, middle, and posterior cerebral arteries symmetrically. All three cases showed to a variable extent brain warts, molecular layer ectopias, and focal architectonic dysplasia identical to those seen in the male cases. Two women had primary brain neoplasms, an oligodendroglioma and a low-grade astrocytoma, respectively, and two women showed small angiomas. Reexamination of previously reported male cases disclosed one with myelinated glial scars. Two control brains with asymmetrical plana temporale showed myelinated glial scars as well. The significance of the anatomical findings is discussed, and possible etiological factors are considered with known effects of autoimmune diseases on the nervous system.