Basolateral amygdala lesions abolish mutual reward preferences in rats
Basolateral amygdala lesions abolish mutual reward preferences in rats
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DOI：
10.1016/j.nlm.2015.11.004
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发表时间：
2016-01-01
影响因子：
2.7
通讯作者：
Kalenscher, Tobias
中科院分区：
文献类型：
--
作者：
Hernandez-Lallement, Julen;van Wingerden, Marijn;Kalenscher, Tobias
在最近的一项研究中，我们证明了大鼠在亲社会选择任务中更喜欢相互奖励。在这里，采用相同的任务，我们表明，基底外侧杏仁核的完整性是必要的相互奖励偏好的表达。演员大鼠接受双侧兴奋性毒性（n =12）或假病变（n = 10），靶向基底外侧杏仁核，并随后在亲社会选择任务中进行测试，其中它们可以决定奖励（“双方奖励”）或不奖励伴侣大鼠（“自己的奖励”），任何选择都产生相同的奖励给演员自己。为了操纵社会背景和控制的二级强化源，演员大鼠配对的合作伙伴大鼠（合作伙伴条件）或与无生命的大鼠玩具（玩具条件）。假手术动物揭示了一个显着的偏好都奖励选项的合作伙伴的条件，但不是在玩具的条件。杏仁核损伤的动物表现出显着较低的双方奖励的喜好比假组的合作伙伴，但不是在玩具的条件下，这表明基底外侧杏仁核是必要的相互奖励的偏好表达。重要的是，在同一实验设置中的奖励幅度辨别任务中，假手术和杏仁核损伤的动物都更喜欢大的奖励而不是小的奖励，这表明杏仁核损伤的影响仅限于社会背景下的决策，而自我导向的行为不受影响。(C)2015爱思唯尔公司All rights reserved.
In a recent study, we demonstrated that rats prefer mutual rewards in a Prosocial Choice Task. Here, employing the same task, we show that the integrity of basolateral amygdala was necessary for the expression of mutual reward preferences. Actor rats received bilateral excitotoxic (n =12) or sham lesions (n = 10) targeting the basolateral amygdala and were subsequently tested in a Prosocial Choice Task where they could decide between rewarding ("Both Reward") or not rewarding a partner rat ("Own Reward"), either choice yielding identical reward to the actors themselves. To manipulate the social context and control for secondary reinforcement sources, actor rats were paired with either a partner rat (partner condition) or with an inanimate rat toy (toy condition). Sham-operated animals revealed a significant preference for the Both-Reward-option in the partner condition, but not in the toy condition. Amygdala-lesioned animals exhibited significantly lower Both-Reward preferences than the sham group in the partner but not in the toy condition, suggesting that basolateral amygdala was required for the expression of mutual reward preferences. Critically, in a reward magnitude discrimination task in the same experimental setup, both sham-operated and amygdala-lesioned animals preferred large over small rewards, suggesting that amygdala lesion effects were restricted to decision making in social contexts, leaving self-oriented behavior unaffected. (C) 2015 Elsevier Inc. All rights reserved.