Vitamin D levels and markers of arterial dysfunction in HIV.
Vitamin D levels and markers of arterial dysfunction in HIV.
复制标题
HIV 患者的维生素 D 水平和动脉功能障碍标志物。
DOI：
10.1089/aid.2011.0086
复制
发表时间：
2012
影响因子：
1.5
通讯作者：
Chow,Dominic
中科院分区：
文献类型：
--
作者：
Shikuma,CeciliaM;Seto,Todd;Liang,Chin-Yuan;Bennett,Kara;DeGruttola,Victor;Gerschenson,Mariana;Stein,JamesH;Budoff,Matthew;Hodis,HowardN;Delaney,JosephAC;Ogata-Arakaki,Debra;Pramyothin,Pornpoj;Chow,Dominic
HIV感染者维生素D水平低，心血管（CVD）风险增加。我们在接受稳定抗逆转录病毒（ARV）治疗的HIV感染者中研究了维生素D和动脉功能障碍的三个标志物之间的关系。通过荧光免疫测定法（DiaSorin）评估了100名参加夏威夷艾滋病毒-心血管老化队列研究的受试者的25-羟基维生素D [25（OH）D]水平，该队列研究的受试者年龄≥40岁，接受稳定（≥6个月）抗逆转录病毒治疗。检测25（OH）D水平与肱动脉血流介导的舒张功能（FMD）、右颈总动脉内膜中层厚度（cIMT）和冠状动脉钙化（CAC）的关系。分析方法包括Pearson相关性、Kruskal-Wallis检验、相对风险和线性回归模型。该队列为86%的男性和60%的白色，中位年龄为52岁，CD 4为510个细胞/mm 3。25（OH）D的中位（Q1，Q3）水平为27.9 ng/ml（21.8，38.3）。有72个FMD、50个cIMT和90个CAC测量值可用于分析。25（OH）D水平与FMD显著相关（r= 0.30，p =0.01），但与cIMT无相关性（r=-0.05，p =0.76）。在线性回归模型中，FMD风险评分减弱了FMD与25（OH）D之间的关系。25（OH）D水平较低者发生CAC的风险略高（RR= 1.02，p =0.04）。在CAC患者中，较低的25（OH）D水平与较高的CAC评分无关（p=0.36）。较低的维生素D水平与HIV感染者亚临床动脉功能障碍的证据有关。这些发现的重要性值得进一步调查。
HIV-infected patients have low vitamin D levels as well as an increase in cardiovascular (CVD) risk. We examined the relationship between vitamin D and three markers of arterial dysfunction among HIV-infected individuals on stable antiretroviral (ARV) therapy. Levels of 25-hydroxyvitamin D [25(OH)D] were assessed by chemiluminescent immunoassay (DiaSorin) in 100 enrollees into the Hawaii Aging with HIV-Cardiovascular Cohort Study, a cohort of HIV-infected subjects age ≥40 years on stable (≥6 months) ARV therapy. The relationships between 25(OH)D levels and brachial artery flow-mediated dilation (FMD), right common carotid artery intima-media thickness (cIMT), and coronary artery calcium (CAC) were examined. Analytical methods included Pearson's correlations, Kruskal–Wallis tests, relative risks, and linear regression models. The cohort was 86% male and 60% white with a median age of 52 years and CD4 of 510 cells/mm3. The median (Q1, Q3) level of 25(OH)D was 27.9 ng/ml (21.8, 38.3). There were 72 FMD, 50 cIMT, and 90 CAC measurements available for analyses. A significant correlation was observed between 25(OH)D levels and FMD (r=0.30,p=0.01) but not with cIMT (r=−0.05,p=0.76). In a linear regression model, Framingham risk score attenuated the relationship between FMD and 25(OH)D. Those with lower 25(OH)D levels were at slightly higher risk of having CAC (RR=1.02,p=0.04). Among those with CAC, lower 25(OH)D levels were not associated with higher CAC scores (p=0.36). Lower vitamin D levels are associated with evidence of subclinical arterial dysfunction in HIV-infected individuals. The significance of these findings warrants further investigation.