Heritability of daytime cortisol levels in children
Heritability of daytime cortisol levels in children
复制标题
DOI：
10.1023/a:1025321609994
复制
发表时间：
2003-07-01
影响因子：
2.6
通讯作者：
Boomsma, DI
中科院分区：
文献类型：
--
作者：
Bartels, M;de Geus, EJC;Boomsma, DI
在精神病理学研究中，压力荷尔蒙皮质醇水平的个体差异作为一个解释变量发挥着重要作用。相对较少的研究关注皮质醇水平的个体差异和这些差异的病因，特别是其可能的遗传基础。所有这些研究都是在成年人中进行的。本研究的目的是评估遗传和环境对12岁儿童基础皮质醇水平的影响。为此，连续两天在180对双胞胎样本中收集了4份唾液皮质醇样本。在一天中不同时间点的皮质醇水平之间存在低相关性。一个显着的遗传贡献被发现的基础皮质醇水平的变化在上午和下午的样品，但不是在晚上的样品。男孩和女孩的遗传率没有差异，在觉醒后45分钟左右采集的样本中，皮质醇水平的遗传率最高（60%）。这种皮质醇觉醒反应为寻找可能影响儿童下丘脑-垂体肾上腺皮质功能的基因提供了有用的内表型。
Individual differences in the level of the stress hormone cortisol play a prominent role as an explanatory variable in studies on psychopathology. Relatively few studies have paid attention to individual differences in cortisol levels and the etiology of these differences, in particular their possible genetic basis. All these studies have been in adults. The aim of this study was to estimate genetic and environmental influences on basal cortisol levels in 12-year-old children. To this end, four samples of salivary cortisol were collected on two consecutive days in a sample of 180 twin pairs. Low correlations were found between cortisol levels at different points in time during the day. A significant genetic contribution was found to the variation of basal cortisol levels in the morning and afternoon samples, but not in the evening sample. Heritability did not differ for boys and girls and was highest (60%) for cortisol levels during the sample taken about 45 minutes after awakening. This cortisol awakening response provides a useful endophenotype in the search for genes that may affect hypothalamic-pituitary adrenocortical functioning in children.