EBV and systemic lupus erythematosus: A new perspective
EBV and systemic lupus erythematosus: A new perspective
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DOI：
10.4049/jimmunol.174.11.6599
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发表时间：
2005-06-01
影响因子：
4.4
通讯作者：
Thorley-Lawson, DA
中科院分区：
文献类型：
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作者：
Gross, AJ;Hochberg, D;Thorley-Lawson, DA
我们提出EBV利用成熟B细胞生物学进入记忆B细胞作为持续感染的位点。该模型的一个核心特征是EBV使其基因表达谱适应其所在B细胞的状态，并且感染水平随时间保持稳定。这使我们质疑成熟B细胞的行为或调节的变化是否会改变EBV持久性的状态。为了研究这一点，我们研究了系统性红斑狼疮（SLE），一种以免疫功能障碍为特征的疾病，对EBV感染的影响。我们发现SLE患者血液中ebv感染细胞的频率异常高，这与SLE疾病爆发的发生有关。虽然SLE患者感染细胞的频率与免疫抑制患者相当，但SLE的效果与免疫抑制治疗无关。在SLE患者血液中也检测到病毒裂解（BZLF1）和潜伏期（潜伏期膜蛋白1和2a）基因的异常表达。我们得出结论，EBV感染在SLE患者中的异常调节反映了病毒对免疫系统扰动的敏感性。
We have proposed that EBV uses mature B cell biology to access memory B cells as a site of persistent infection. A central feature of this model is that EBV adapts its gene expression profile to the state of the B cell it resides in and that the level of infection is stable over time. This led us to question whether changes in the behavior or regulation of mature B cells would alter the state of EBV persistence. To investigate this, we studied the impact of systemic lupus erythematosus (SLE), a disease characterized by immune dysfunction, on EBV infection. We show that patients with SLE have abnormally high frequencies of EBV-infected cells in their blood, and this is associated with the occurrence of SLE disease flares. Although patients with SLE have frequencies of infected cells comparable to those seen in inummosuppressed patients, in SLE the effect was independent of immunosuppressive therapy. Aberrant expression of viral lytic (BZLF1) and latency (latency membrane proteins 1 and 2a) genes was also detected in the blood of SLE patients. We conclude that the abnormal regulation of EBV infection in SLE patients reflects the sensitivity of the virus to perturbation of the immune system.