Model systems for activation of nucleic acid encoded prodrugs
Model systems for activation of nucleic acid encoded prodrugs
复制标题
DOI：
10.1002/cmdc.200700013
复制
发表时间：
2007-06-01
期刊：
影响因子：
3.4
通讯作者：
Gothelf, Kurt V.
中科院分区：
文献类型：
--
作者：
Jacobsen, Mikkel F.;Clo, Emiliano;Gothelf, Kurt V.
开发更有选择性的化疗药物用于恶性疾病的良性治疗是非常需要的。近年来，人们已经设计出了通过模板化化学或光化学反应从核酸偶联物中释放小分子药物的模型系统。这些系统的共同点是，化学计量或催化药物释放是由核酸互补链之间的高度选择性杂交控制的。本文概述了核酸模板释放反应这一新领域的概念。
The development of more selective chemotherapeutic agents for i benign treatments of malicious diseases is highly desirable. In recent years model systems for the release of small molecule drugs from nucleic acid conjugates by templated chemical or photochemical reactions hove been designed. Common for these systems is that the stoichiometric or catalytic drug release is controlled by the highly selective hybridization between complementary strands of nucleic acids. Herein, the concepts of the new field of nucleic acid templated release reactions are outlined.