2 ALIEN HAND SYNDROMES
2 ALIEN HAND SYNDROMES
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DOI：
10.1212/wnl.42.1.19
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发表时间：
1992-01-01
期刊：
影响因子：
9.9
通讯作者：
HABER, LD
中科院分区：
文献类型：
--
作者：
FEINBERG, TE;SCHINDLER, RJ;HABER, LD
回顾20例异手综合征（AHS）的临床特点和神经解剖学的报告和我们自己的病人证实，AHS实际上是两个不同的综合征。额叶AHS发生在优势手;与反射性抓握、摸索和强迫性操作工具有关;并且是由辅助运动区、前扣带回和优势半球的内侧前额叶皮层以及前胼胝体的损伤引起的。胼胝体AHS的主要特征是双手间的冲突，只需要一个前胼胝体病变。在优势肢体的额叶AHS的发生可以解释为优势肢体探索反射的增加趋势，再加上释放不对称分布，占主导地位的非优势半球抑制。胼胝体AHS最好解释为在需要优势半球控制的行为中表现出的半球断开。
Review of the clinical characteristics and neuroanatomy of 20 reported cases of alien hand syndrome (AHS) and a patient of our own confirm that AHS is actually two distinct syndromes. Frontal AHS occurs in the dominant hand; is associated with reflexive grasping, groping, and compulsive manipulation of tools; and results from damage to the supplementary motor area, anterior cingulate gyrus, and medial prefrontal cortex of the dominant hemisphere and anterior corpus callosum. Callosal AHS is characterized primarily by intermanual conflict and requires only an anterior callosal lesion. The occurrence of frontal AHS in the dominant limb can be explained by an increased tendency for dominant limb exploratory reflexes coupled with release from an asymmetrically distributed, predominant nondominant-hemisphere inhibition. Callosal AHS is best explained by hemispheric disconnection manifested during behaviors requiring dominant-hemisphere control.