Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis.
Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis.
复制标题
自由流动中剪切介导的血小板活化：介导心血管植入物血栓形成的新兴细胞机械生物学机制的视角。
DOI：
10.1016/j.jbiomech.2016.11.016
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发表时间：
2017
影响因子：
2.4
通讯作者：
Bluestein,Danny
中科院分区：
文献类型：
--
作者：
Slepian,MarvinJ;Sheriff,Jawaad;Hutchinson,Marcus;Tran,Phat;Bajaj,Naing;Garcia,JoeGN;ScottSaavedra,S;Bluestein,Danny
剪切介导的血小板活化（SMPA）是植入式心血管治疗器械血栓形成的核心。尽管发病率和死亡率与血栓形成的这些设备，我们的了解机制SMPA，特别是在自由流动的血液，仍然有限。在这里，我们提出并讨论了一系列新兴的机制，考虑在超生理剪切下的“自由流动”激活。这些机制的进一步定义和操作将为限制SMPA和提高植入器械整体安全性的新型药理学和机械策略提供机会。
Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.