Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomised comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesions.
Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomised comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesions.
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用于监测溃疡性结肠炎的内窥镜三模态成像：高分辨率内窥镜和自发荧光成像对肿瘤检测的随机比较；以及用于病变分类的窄带成像评估。
DOI：
10.1136/gut.2007.144097
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发表时间：
2008-08
期刊：
影响因子：
24.5
通讯作者：
Dekker, E.
中科院分区：
文献类型：
--
作者：
van den Broek, F. J. C.;Fockens, P.;van Eeden, S.;Reitsma, J. B.;Hardwick, J. C. H.;Stokkers, P. C. F.;Dekker, E.
内窥镜三模式成像（ETMI）包括白色光内窥镜（WLE）、自体荧光成像（AFI）和窄带成像（NBI）。评估ETMI对长期溃疡性结肠炎患者肿瘤的检测和分类价值。串联结肠镜检查的随机比较试验。荷兰阿姆斯特丹学术医疗中心。50例溃疡性结肠炎患者接受了ETMI监测结肠镜检查。每个结肠段检查两次，一次用AFI，一次用WLE，随机顺序。通过NBI检查所有检测到的病变以进行Kudo凹陷模式分析，并进行额外的随机活检。AFI和WLE的瘤样病变漏诊率，以及NBI的Kudo分型准确性。在分配到检查与AFI第一（n = 25），10个肿瘤病变的患者中，主要检测。 随后的WLE未检测到其他肿瘤。在首先进行WLE检查的患者中（n = 25），检测到3处肿瘤性病变;随后进行AFI检查，增加了3处肿瘤性病变。 AFI和WLE的瘤样病变漏诊率分别为0%和50%（p = 0.036）。 NBI Kudo分类的敏感性和特异性分别为75%和81%;然而，所有瘤变在AFI上呈紫色（敏感性100%）。随机活检未发现其他肿瘤患者。自体荧光成像提高了溃疡性结肠炎患者肿瘤的检出率，并降低了随机活检的检出率。通过NBI进行的凹陷模式分析对组织学的预测具有中等准确性，而AFI颜色在排除肿瘤的存在方面似乎很有价值。ISRCTN05272746
Endoscopic tri-modal imaging (ETMI) incorporates white light endoscopy (WLE), autofluorescence imaging (AFI) and narrow-band imaging (NBI). To assess the value of ETMI for the detection and classification of neoplasia in patients with longstanding ulcerative colitis. Randomised comparative trial of tandem colonoscopies. Academic Medical Centre Amsterdam, Netherlands. Fifty patients with ulcerative colitis underwent surveillance colonoscopy with ETMI. Each colonic segment was inspected twice, once with AFI and once with WLE, in random order. All detected lesions were inspected by NBI for Kudo pit pattern analysis and additional random biopsies were taken. Neoplasia miss-rates of AFI and WLE, and accuracy of the Kudo classification by NBI. Among patients assigned to inspection with AFI first (n = 25), 10 neoplastic lesions were primarily detected. Subsequent WLE detected no additional neoplasia. Among patients examined with WLE first (n = 25), three neoplastic lesions were detected; subsequent inspection with AFI added three neoplastic lesions. Neoplasia miss-rates for AFI and WLE were 0% and 50% (p = 0.036). The Kudo classification by NBI had a sensitivity and specificity of 75% and 81%; however, all neoplasia was coloured purple on AFI (sensitivity 100%). No additional patients with neoplasia were detected by random biopsies. Autofluorescence imaging improves the detection of neoplasia in patients with ulcerative colitis and decreases the yield of random biopsies. Pit pattern analysis by NBI has a moderate accuracy for the prediction of histology, whereas AFI colour appears valuable in excluding the presence of neoplasia. ISRCTN05272746
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影响因子：
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作者：
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