Covid-19.bioreproducibility.org: A web resource for SARS-CoV-2-related structural models.

Covid-19.bioreproducibility.org: A web resource for SARS-CoV-2-related structural models.
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DOI:
10.1002/pro.3959
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发表时间:
2021-01
期刊:
Protein science : a publication of the Protein Society
影响因子:
--
通讯作者:
Minor W
Minor W
中科院分区:
其他
文献类型:
--
作者:
Brzezinski D;Kowiel M;Cooper DR;Cymborowski M;Grabowski M;Wlodawer A;Dauter Z;Shabalin IG;Gilski M;Rupp B;Jaskolski M;Minor W

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新冠肺炎大流行引发了许多旨在了解SARS-CoV-2病毒并最终开发治疗方法的科学活动。结构生物学家已经确定了数百种与这种冠状病毒相关的蛋白质和核酸的实验X射线、冷冻-EM和核磁共振结构,而且这个数字还在增长。为了帮助生物医学研究人员在结构模型的洪流中导航,他们可能不一定是结构生物学方面的专家,我们创建了一个在线资源covid19.bioreducibility.org,它汇集了专家验证的关于SARS-CoV-2相关大分子模型的信息。在本文中,我们描述了该Web资源以及用于评估其中所示结构的一套工具和方法。
The COVID‐19 pandemic has triggered numerous scientific activities aimed at understanding the SARS‐CoV‐2 virus and ultimately developing treatments. Structural biologists have already determined hundreds of experimental X‐ray, cryo‐EM, and NMR structures of proteins and nucleic acids related to this coronavirus, and this number is still growing. To help biomedical researchers, who may not necessarily be experts in structural biology, navigate through the flood of structural models, we have created an online resource, covid19.bioreproducibility.org, that aggregates expert‐verified information about SARS‐CoV‐2‐related macromolecular models. In this article, we describe this web resource along with the suite of tools and methodologies used for assessing the structures presented therein.
DOI: 10.1038/nprot.2018.018
发表时间: 2018-05
期刊: Nature protocols
影响因子: 14.8
作者:
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