Moderation of prior exposure to trauma on the inverse relationship between callous-unemotional traits and amygdala responses to fearful expressions: an exploratory study.
Moderation of prior exposure to trauma on the inverse relationship between callous-unemotional traits and amygdala responses to fearful expressions: an exploratory study.
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DOI：
10.1017/s0033291718000156
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发表时间：
2018-11
影响因子：
6.9
通讯作者：
Blair RJR
中科院分区：
文献类型：
--
作者：
Meffert H;Thornton LC;Tyler PM;Botkin ML;Erway AK;Kolli V;Pope K;White SF;Blair RJR
先前的研究表明，杏仁核对恐惧表情的反应与行为问题青年的冷酷无情（CU）特征（即减少内疚和同情）水平呈负相关。然而，一些研究表明，病理生理学和CU性状之间的关系可能是不同的，在那些年轻人有显着的先前创伤暴露。在实验1中，72名具有不同程度的破坏性行为和创伤暴露的青年在观看变形恐惧表情（0，50，100，150恐惧）时执行性别歧视任务，并记录血氧水平依赖反应。在实验2中，这些青年中有66人完成了社会目标任务，该任务测量了参与者在激发社会情境中对特定社会目标重要性的自我报告。在实验1中，一个显着的CU特质的创伤暴露的相互作用，观察右杏仁核;恐惧强度调制杏仁核反应消极预测CU特质的那些年轻人与低水平的创伤，但积极预测CU特质的那些高水平的创伤。在实验2中，一个自举模型揭示了恐惧强度杏仁核反应通过CU特质对社会目标重要性的间接影响被先前的创伤暴露所调节。这项研究，而探索性的，表明与CU性状的病理生理学不同，在青年作为一个功能，以前的创伤暴露。这些数据表明，在评估高CU特征的青年的潜在干预措施时，应考虑先前的创伤暴露。
Previous work has shown that amygdala responsiveness to fearful expressions is inversely related to level of callous-unemotional (CU) traits (i.e. reduced guilt and empathy) in youth with conduct problems. However, some research has suggested that the relationship between pathophysiology and CU traits may be different in those youth with significant prior trauma exposure. In experiment 1, 72 youth with varying levels of disruptive behavior and trauma exposure performed a gender discrimination task while viewing morphed fear expressions (0, 50, 100, 150 fear) and Blood Oxygenation Level Dependent responses were recorded. In experiment 2, 66 of these youth performed the Social Goals Task, which measures self-reports of the importance of specific social goals to the participant in provoking social situations. In experiment 1, a significant CU traits-by-trauma exposure interaction was observed within right amygdala; fear intensity-modulated amygdala responses negatively predicted CU traits for those youth with low levels of trauma but positively predicted CU traits for those with high levels of trauma. In experiment 2, a bootstrapped model revealed that the indirect effect of fear intensity amygdala response on social goal importance through CU traits is moderated by prior trauma exposure. This study, while exploratory, indicates that the pathophysiology associated with CU traits differs in youth as a function of prior trauma exposure. These data suggest that prior trauma exposure should be considered when evaluating potential interventions for youth with high CU traits.