Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis
Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis
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DOI：
10.1097/01.iop.0000169426.57497.24
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发表时间：
2005-07-01
影响因子：
2
通讯作者：
Reddy, VAP
中科院分区：
文献类型：
--
作者：
Murthy, R;Honavar, SG;Reddy, VAP
一名55岁的亚洲印度女性，患有左下眼睑复发性皮脂腺癌伴眼眶延伸和区域淋巴结转移，接受卡铂和5-氟尿嘧啶联合新辅助化疗。化疗3个周期后行保留眼睑的眶内容物摘除术，然后对区域淋巴结进行放疗。随后，给予3个周期的辅助化疗。新辅助化疗使眼睑和眼眶肿瘤体积显著缩小，使保留眼睑的眼眶摘除术成为可能。化疗也使病人免于根治性颈淋巴结清扫术。患者发病率有限，在26个月随访时无局部、区域和全身疾病。
A 55-year-old Asian Indian woman who had recurrent sebaceous gland carcinoma of the left lower eyelid with orbital extension and regional lymph node metastasis was treated with neoadjuvant chemotherapy, using a combination of carboplatin and 5-fluorouracil. Eyelid-sparing orbital exenteration was performed after 3 cycles of chemotherapy, followed by radiotherapy to the regional lymph nodes. Subsequently, 3 cycles of adjuvant chemotherapy were administered. Significant eyelid and orbital tumor volume reduction was achieved with neoadjuvant chemotherapy, making eyelid-sparing orbital exenteration possible. Chemotherapy also spared the patient from radical neck dissection. The patient had limited morbidity and was free of local, regional, and systemic disease at 26 months of follow-up.