Higher Biomarker-Calibrated Protein Intake Is Not Associated with Impaired Renal Function in Postmenopausal Women
Higher Biomarker-Calibrated Protein Intake Is Not Associated with Impaired Renal Function in Postmenopausal Women
复制标题
DOI：
10.3945/jn.110.135814
复制
发表时间：
2011-08-01
影响因子：
4.2
通讯作者：
Prentice, Ross L.
中科院分区：
文献类型：
--
作者：
Beasley, Jeannette M.;Aragaki, Aaron K.;Prentice, Ross L.
随着年龄的增长，肾功能有下降的趋势，表现为肾小球滤过率降低。高蛋白摄入可能会导致持续的高滤过，从而进一步加重肾脏的压力。为了研究饮食蛋白质是否与肾功能受损有关，我们使用了妇女健康倡议观察性研究(n=2419)内的2项嵌套病例对照研究的数据。我们使用FED估计蛋白质摄入量，并使用半胱氨酸氨基转移酶C估计肾小球滤过率(EGFR)。为了解释最初的研究设计，采用了逆概率权重。使用能量和蛋白质摄入量的生物标记物对自我报告的能量和蛋白质进行校准。通过加权线性和Logistic回归模型估计蛋白质摄入量和肾功能之间的关系。平均校正蛋白质摄入量(Mean+/-SD)为1.1+/-0.2g/(kg·d)。12%的女性肾功能受损。肾功能受损的几率，定义为EGFR<；60毫升/(分钟1.73毫升(2))，与校准的蛋白质摄入量无关。当EGFR连续建模时，当蛋白质以绝对值(g/d)或相对于能量(蛋白质%能量/d)表达时，与校准的蛋白质没有关联，但相对于体重[g/(kg体重.d)]的蛋白质与较高的EGFR相关。没有证据表明年龄、BMI或一般健康状况会影响疗效。这些数据表明，在没有慢性肾脏疾病诊断的绝经后妇女中，较高的蛋白质摄入量与肾功能受损无关。J.Nutr.141：1502-1507,2011。
With aging, renal function tends to decline, as evidenced by reduced glomerular filtration rate. High-protein intake may further stress the kidneys by causing sustained hyperfiltration. To investigate whether dietary protein is associated with impaired renal function, we used data from 2 nested case-control studies within the Women's Health Initiative Observational Study (n = 2419). We estimated protein intake using a FED and estimated glomerular filtration rate (eGFR) from cystatin C. To account for the original study designs, inverse probability weights were applied. Self-reported energy and protein were calibrated using biomarkers of energy and protein intake. Associations between protein intake and renal function were estimated by weighted linear and logistic regression models. Average calibrated protein intake (mean +/- SD) was 1.1 +/- 0.2 g/(kg body weight.d). Twelve percent In = 292) of women had impaired renal function. The odds of impaired renal function, defined as eGFR < 60 mL/(min.1.73m(2)), was not associated with calibrated protein intake. When eGFR was modeled continuously, there was no association with calibrated protein when protein was expressed in absolute (g/d) or relative to energy (protein % energy/d), but protein relative to body weight [g/(kg body weight.d)] was associated with higher eGFR. There was no evidence for effect modification by age, BMI, or general health status. These data suggest higher protein intake is not associated with impaired renal function among postmenopausal women without a diagnosis of chronic kidney disease. J. Nutr. 141: 1502-1507, 2011.