Zika Virus, Chikungunya Virus, and Dengue Virus in Cerebrospinal Fluid from Adults with Neurological Manifestations, Guayaquil, Ecuador.
Zika Virus, Chikungunya Virus, and Dengue Virus in Cerebrospinal Fluid from Adults with Neurological Manifestations, Guayaquil, Ecuador.
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DOI：
10.3389/fmicb.2017.00042
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发表时间：
2017-01-01
影响因子：
5.2
通讯作者：
Zambrano, Hector
中科院分区：
文献类型：
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作者：
Acevedo, Nathalie;Waggoner, Jesse;Zambrano, Hector
寨卡病毒（ZIKV）、基孔肯雅病毒（CHIKV）和登革热病毒（DENV）与涉及急性神经系统疾病的临床表现有关。在目前的研究中，我们在Luis Vernaza医院（厄瓜多尔Guayaquil）急诊室或重症监护病房收治的患者脑脊液样本中发现了ZIKV、CHIKV和DENV，这些患者有神经系统症状和/或对急性虫媒病毒感染的担忧。16例患者中有12例检测到一种或多种病毒的病毒RNA。6名患者被诊断为脑膜炎或脑炎，3名患有格林-巴利综合征，1名患有中枢神经系统血管炎。另外两名患者有包括头痛在内的全身性发热性疾病，提示进行脑脊液检测。两名被诊断患有脑炎和脑膜脑炎的患者在住院期间死亡。这些病例显示了与ZIKV、CHIKV和DENV感染相关的神经学表现的广度和重要性。
Zika virus (ZIKV), chikungunya virus (CHIKV), and dengue virus (DENV) have been associated with clinical presentations that involve acute neurological complaints. In the current study, we identified ZIKV, CHIKV, and DENV in cerebrospinal fluid (CSF) samples from patients admitted to the Hospital Luis Vernaza (Guayaquil, Ecuador) to the Emergency Room or the Intensive Care Unit, with neurological symptoms and/or concern for acute arboviral infections. Viral RNA from one or more virus was detected in 12/16 patients. Six patients were diagnosed with meningitis or encephalitis, three with Guillain-Barre Syndrome, and one with CNS vasculitis. Two additional patients had a systemic febrile illness including headache that prompted testing of CSF. Two patients, who were diagnosed with encephalitis and meningoencephalitis, died during their hospitalizations. These cases demonstrate the breadth and significance of neurological manifestations associated with ZIKV, CHIKV, and DENV infections.