Hepatitis B virus infection in cultured human lymphoblastoid cells.
Hepatitis B virus infection in cultured human lymphoblastoid cells.
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DOI：
10.1126/science.6867736
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发表时间：
1983-08
期刊：
影响因子：
56.9
通讯作者：
J. Romet‐Lemonne;M. McLane;E. Elfassi;W. Haseltine;J. Azócar;M. Essex
中科院分区：
文献类型：
--
作者：
J. Romet‐Lemonne;M. McLane;E. Elfassi;W. Haseltine;J. Azócar;M. Essex
由于假设肝脏肝细胞可能通过与受感染的巨噬细胞直接接触而在体内被乙型肝炎病毒（HBV）感染，因此研究了造血来源的循环细胞可能易受HBV感染的可能性。在 HBV 感染者的骨髓细胞抽吸物中鉴定出 HBV 表面抗原呈阳性的细胞。这些细胞用于制备含有 HBV 感染细胞的类淋巴母细胞悬浮培养物。
Since it has been postulated that liver hepatocytes may become infected by hepatitis B virus (HBV) in vivo through direct contact with infected macrophages, the possibility that a circulating cell of hematopoietic origin might be susceptible to infection with HBV was investigated. Cells positive for HBV surface antigen were identified in aspirates of bone marrow cells from people infected with HBV. These cells were used to prepare a lymphoblastoid suspension culture that contains HBV-infected cells.