Engineered cell-cell communication and its applications.
Engineered cell-cell communication and its applications.
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DOI：
10.1007/10_2013_249
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Stephen Payne;L. You
中科院分区：
文献类型：
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作者：
Stephen Payne;L. You
<? xm-replace_text {标题}？>摘要在过去的几十年里，生物学家们越来越重视细胞间通讯在自然系统中的基本作用，从原核生物膜到真核生物发育系统和神经网络。从工程的角度来看，使用细胞-细胞通信提供了一个机会，工程更复杂和强大的功能，使用蜂窝组件。事实上，这种策略已在合成生物学中被采用，用于创建对一个或多个种群的时空动态进行编程的多样化基因电路。诸如此类的基因电路可以提供关于基本生物学问题和主题的见解，或者作为新应用的基础。图形摘要
<?xm-replace_text {Heading}?>AbstractOver the past several decades, biologists have become more appreciative of the fundamental role of intercellular communication in natural systems spanning prokaryotic biofilms to eukaryotic developmental systems and neurological networks. From an engineering perspective, the use of cell–cell communication provides an opportunity to engineer more complex and robust functions using cellular components. Indeed, this strategy has been adopted in synthetic biology in the creation of diverse gene circuits that program spatiotemporal dynamics in one or multiple populations. Gene circuits such as these may offer insights regarding basic biological questions and motifs or serve as a basis for novel applications.Graphical Abstract