High altitude and spontaneous preterm birth
High altitude and spontaneous preterm birth
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DOI：
10.1016/0020-7292(96)02673-2
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发表时间：
1996-07-01
影响因子：
3.8
通讯作者：
Khalid, MEM
中科院分区：
文献类型：
--
作者：
Ali, KZM;Ali, ME;Khalid, MEM
目的：探讨高原与自发性早产的关系。方法：在沙特阿拉伯南部城市Abha收集了11例无临床易感原因的高海拔自发性早产患者的胎盘。采用周期性酸-希夫染色和苏木精-伊红染色切片对胎盘进行组织学检查。结果：胎盘标本组织学显示，终绒毛上存在大量合胞结（45.4 +/- 13.3%）和细胞滋养层细胞（52.7 +/- 15.2%）。结论：合胞结和细胞滋养层细胞形成增强是胎盘缺氧的组织学特征，可能继发于产妇高原缺氧所致的缺氧。由于胎盘缺氧与自发性早产的发生率增加有关，我们认为高海拔可能与自发性早产的病因有关。
Objective: To study the association between high altitude and spontaneous preterm birth. Methods: Eleven placentas from cases of high altitude (3000 m) spontaneous preterm deliveries with no clinical predisposing cause were collected in Abha, a city of southern Saudi Arabia. The placentas were examined histologically using sections stained by periodic acid-Schiff and hematoxylin-eosin. The mean percentages of villi with syncytial knots and cytotrophoblastic cells were determined, Results: Histology of the placenta samples showed an excessive formation of syncytial knots (45.4 +/- 13.3%) and cytotrophoblastic cells (52.7 +/- 15.2%) at terminal villi. Conclusion: The enhanced formation of syncytial knots and cytotrophoblastic cells is a histological feature of placental hypoxia, which may be secondary to maternal hypoxia resulting from high altitude hypoxia. Since placental hypoxia is associated with an increased incidence of spontaneous preterm birth, we suggest that high altitude may be involved in the etiology of spontaneous preterm birth.