2-AMINO-4-PHOSPHONOBUTYRIC ACID - A NEW PHARMACOLOGICAL TOOL FOR RETINA RESEARCH
2-AMINO-4-PHOSPHONOBUTYRIC ACID - A NEW PHARMACOLOGICAL TOOL FOR RETINA RESEARCH
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DOI：
10.1126/science.6255566
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
MILLER, RF
中科院分区：
文献类型：
--
作者：
SLAUGHTER, MM;MILLER, RF
脊椎动物视网膜中的信息处理发生在两个单独的通道中，称为ON和OFF通道。当从泥小狗（斑节龙）的灌注视网膜眼杯制备物中获得细胞内电生理记录时，向沐浴培养基中添加2-氨基-4-磷酸丁酸可以阻断ON通道中的所有反应，但保留完整的OFF反应，包括OFF神经节细胞放电。2-氨基-4-膦酰基丁酸通过模拟内源性光感受器递质阻断ON双极细胞的光反应。
Information processing in the vertebrate retina occurs in 2 separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mudpuppy (Necturus maculosus) the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.