Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults
Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults
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DOI：
10.1016/j.clnu.2013.02.011
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发表时间：
2013-10-01
影响因子：
6.3
通讯作者：
Wolfe, Robert R.
中科院分区：
文献类型：
--
作者：
Deutz, Nicolaas E. P.;Pereira, Suzette L.;Wolfe, Robert R.
背景资料：由于长期卧床休息导致的肌肉质量损失降低了老年人的功能能力，增加了住院发病率和死亡率。目的：确定HMB（一种亮氨酸代谢物）是否能够在完全卧床休息期间减弱健康老年人的肌肉衰退。设计：采用随机、对照、双盲、平行组设计，在24例健康体检者中进行了研究。（SPPB >= 9）老年受试者（20名女性，4名男性），完全卧床休息10天，然后进行8周的阻力训练康复。实验组中的受试者用HMB（钙盐，1.5g，每天两次-总共3g/天）治疗。对照组受试者接受非活性安慰剂粉末治疗。从卧床休息前5天开始提供治疗，直至康复期结束。DXA用于测量身体组成。结果：19名合格的老年人（BMI：21-33;年龄：60-76岁）在卧床休息期结束时可评价（对照组n = 8; Ca-HMB n = 11）。卧床休息导致对照组总瘦体重（LBM）显著降低（2.05 +/- 0.66 kg; p = 0.02，配对t检验）。在排除1例受试者的情况下，用HMB治疗防止了卧床休息期间LBM下降-0.17 +/-0.19 kg; p = 0.23，配对t检验）。治疗组间LBM相对于卧床休息的变化存在统计学显著差异（p = 0.02，ANOVA）。对女性受试者（对照组= 7，HMB = 8）的亚组分析也显示，治疗组之间卧床期间LBM的变化存在显著差异（p = 0.04，ANOVA）。然而，功能参数的差异无法观察到，可能是由于样本量的study.Conclusions：在健康的老年人，HMB补充保留肌肉质量在10天的卧床休息。这些结果需要在更大规模的试验中得到证实。该试验在http://ClinicalTrials.gov注册，编号为NCT 00945581。(C)2013爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background: Loss of muscle mass due to prolonged bed rest decreases functional capacity and increases hospital morbidity and mortality in older adults.Objective: To determine if HMB, a leucine metabolite, is capable of attenuating muscle decline in healthy older adults during complete bed rest.Design: A randomized, controlled, double-blinded, parallel-group design study was carried out in 24 healthy (SPPB >= 9) older adult subjects (20 women, 4 men), confined to complete bed rest for ten days, followed by resistance training rehabilitation for eight weeks. Subjects in the experimental group were treated with HMB (calcium salt, 1.5 g twice daily - total 3 g/day). Control subjects were treated with an inactive placebo powder. Treatments were provided starting 5 days prior to bed rest till the end rehabilitation phase. DXA was used to measure body composition.Results: Nineteen eligible older adults (BMI: 21-33; age: 60-76 year) were evaluable at the end of the bed rest period (Control n = 8; Ca-HMB n = 11). Bed rest caused a significant decrease in total lean body mass (LBM) (2.05 +/- 0.66 kg; p = 0.02, paired t-test) in the Control group. With the exclusion of one subject, treatment with HMB prevented the decline in LBM over bed rest -0.17 +/- 0.19 kg; p = 0.23, paired t-test). There was a statistically significant difference between treatment groups for change in LBM over bed rest (p = 0.02, ANOVA). Sub-analysis on female subjects (Control = 7, HMB = 8) also revealed a significant difference in change in LBM over bed rest between treatment groups (p = 0.04, ANOVA). However, differences in function parameters could not be observed, probably due to the sample size of the study.Conclusions: In healthy older adults, HMB supplementation preserves muscle mass during 10 days of bed rest. These results need to be confirmed in a larger trial.This trial is registered at http://ClinicalTrials.gov under NCT00945581. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.