Pyramidal lesion in the monkey.
Pyramidal lesion in the monkey.
复制标题
DOI：
10.1093/brain/63.1.36
复制
发表时间：
1940-01-01
期刊：
影响因子：
14.5
通讯作者：
Tower, SS
中科院分区：
文献类型：
--
作者：
Tower, SS
在恒河猴的斜方体水平，采用前路手术制作单侧和双侧锥体病变。10只单侧椎体完全切除动物存活2天至32个月。身体对侧的低张性麻痹发生，影响所有躯体和一些内脏功能。突出的特征是肌张力减弱;皮肤反射减弱;缓慢而充分的腱反射仅限于受刺激的肌肉;皮肤温度降低;骨骼肌肉组织的所有表演的启动和执行都有缺陷，消除了非定型成分并消除了手指的所有离散使用。除了累及四肢的肌肉组织外，双侧锥体束病变还可引起轴性肌肉组织极度张力减退;头部不稳，身体下垂，体重减轻。内脏的收缩导致腹部隆起和尾巴下垂。特别令人感兴趣的是动物试图补偿受干扰的运动功能的方法。脊髓锥体的切断中断了皮质脊髓的作用，仅皮质脊髓的作用，因为逆行变性几乎立即停止在病变上方。
Unilateral and bilateral pyramidal lesions were made at the level of the trapezoid body by the anterior approach on the common rhesus monkey. 10 animals with complete unilateral pyramidal section survived from 2 days to 32 mos. Hypo-tonic paresis of the opposite side of the body occurs affecting all somatic, and some visceral function. The outstanding features are diminished muscle tone; diminished cutaneous reflexes; slow, full tendon reflexes restricted to the muscle stimulated; lowered skin temp.; defective initiation and execution of all performance by skeletal musculature with elimination of non-stereotyped components and elimination of all discrete usage of the digits. In addition to involvement of the musculature of all extremities, bilateral p.yramidal lesions cause extreme hypotonia of the axial musculature; the head is unstable, the body sags, the wt. of the viscera causes abdominal bulging and the tail droops. Of special interest are the means whereby the animal attempts to compensate for the disturbed motor function. Sectioning of the medullary pyramids interrupts corticospinal action and that alone, for retrograde degeneration stops almost immediately above the lesion.