Synthesis of Benzannulated [6,6]-Spiroketals by a One-Pot Carbonylative Sonogashira Coupling/Double Annulation Reaction
Synthesis of Benzannulated [6,6]-Spiroketals by a One-Pot Carbonylative Sonogashira Coupling/Double Annulation Reaction
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通过一锅羰基化 Sonogashira 偶联/双环化反应合成苯并环[6,6]-螺缩酮
DOI：
10.1021/acs.orglett.8b03586
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Li Ying
中科院分区：
文献类型：
--
作者：
Xiang Kuirong;Tong Pei;Yan Baorun;Long Lingling;Zhao Chunbo;Zhang Yuan;Li Ying
采用钯催化的Sonogashira羰化偶联反应和双环化反应一步合成了苯并环化的[6，6]-螺酮缩酮。该方案提供了直接和方便的苯并环化的[6，6]-螺缩酮在中等至良好的产率和优异的非对映选择性下，在CO的气球压力在室温下。
A one-pot Pd-catalyzed carbonylative Sonogashira coupling in tandem with double annulation reaction to synthesize benzannulated [6,6]-spiroketals fromo-iodophenols and terminal alkynols or alkynyl phenols was achieved. The protocol provides straightforward and facile access to benzannulated [6,6]-spiroketals in moderate to good yields and excellent diastereoselectivities under balloon pressure of CO at room temperature.