Temporal and spatial tuning of dorsal lateral geniculate nucleus neurons in unanesthetized rats.
Temporal and spatial tuning of dorsal lateral geniculate nucleus neurons in unanesthetized rats.
复制标题
未麻醉大鼠背外侧膝状核神经元的时间和空间调节。
DOI：
10.1152/jn.00812.2014
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发表时间：
2016
影响因子：
2.5
通讯作者：
Reinagel,Pamela
中科院分区：
文献类型：
--
作者：
Sriram,Balaji;Meier,PhilipM;Reinagel,Pamela
背外侧膝状体核（dLGN）神经元的视觉反应特性在几个物种中已经得到了很好的描述，但在大鼠中还没有。需要分析未麻醉大鼠dLGN的反应，以开发解释大鼠视觉行为的定量模型。我们记录了7只未麻醉大鼠dLGN中130个单位的视觉反应。我们报告的响应幅度，时间频率和空间频率的敏感性，在这个人口的细胞。响应于2-Hz视觉刺激，dLGN细胞发射15.9 ± 11.4个尖峰/s（平均值± SD），其被关于平均值的10.7 ± 8.4个尖峰/s调制。全场刺激的最佳时间频率范围为5.8至19.6 Hz的细胞。时间高频截止范围为11.7至33.6 Hz。一些细胞对低时间频率刺激（低通）的反应最好，而另一些则是严格的带通;大多数细胞介于这两个极端之间。在2至4赫兹的时间调制，漂移光栅的空间频率，驱动细胞最好的范围从0.008至0.18周每度（cpd）跨细胞。细胞间的高频截止值范围为0.01至1.07 cpd。大多数单元由测试的最低空间频率最佳地驱动，但许多单元是部分或严格带通的。我们的结论是，在大鼠dLGN的单个单位可以积极响应时间调制高达至少30 Hz和空间细节高达1 cpd. Tuning属性是异质的，但每个下降沿着一个连续的，我们发现没有明显的集群成离散的细胞类型沿着这些尺寸。
Visual response properties of neurons in the dorsolateral geniculate nucleus (dLGN) have been well described in several species, but not in rats. Analysis of responses from the unanesthetized rat dLGN will be needed to develop quantitative models that account for visual behavior of rats. We recorded visual responses from 130 single units in the dLGN of 7 unanesthetized rats. We report the response amplitudes, temporal frequency, and spatial frequency sensitivities in this population of cells. In response to 2-Hz visual stimulation, dLGN cells fired 15.9 ± 11.4 spikes/s (mean ± SD) modulated by 10.7 ± 8.4 spikes/s about the mean. The optimal temporal frequency for full-field stimulation ranged from 5.8 to 19.6 Hz across cells. The temporal high-frequency cutoff ranged from 11.7 to 33.6 Hz. Some cells responded best to low temporal frequency stimulation (low pass), and others were strictly bandpass; most cells fell between these extremes. At 2- to 4-Hz temporal modulation, the spatial frequency of drifting grating that drove cells best ranged from 0.008 to 0.18 cycles per degree (cpd) across cells. The high-frequency cutoff ranged from 0.01 to 1.07 cpd across cells. The majority of cells were driven best by the lowest spatial frequency tested, but many were partially or strictly bandpass. We conclude that single units in the rat dLGN can respond vigorously to temporal modulation up to at least 30 Hz and spatial detail up to 1 cpd. Tuning properties were heterogeneous, but each fell along a continuum; we found no obvious clustering into discrete cell types along these dimensions.