The zygotic mutant tailless affects the anterior and posterior ectodermal regions of the Drosophila embryo.
The zygotic mutant tailless affects the anterior and posterior ectodermal regions of the Drosophila embryo.
复制标题
无尾合子突变体影响果蝇胚胎的前外胚层区域和后外胚层区域。
DOI：
10.1016/0012-1606(86)90108-9
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发表时间：
1986
影响因子：
2.7
通讯作者：
Merriam,JR
中科院分区：
文献类型：
--
作者：
Strecker,TR;Kongsuwan,K;Lengyel,JA;Merriam,JR
隐性合子致死突变定位于3号染色体右臂顶端的100 A5，6-B1，2区域，导致成熟胚胎头部骨骼的咽嵴缩短，第八腹节和尾节消失。虽然它们有正常的体长，但无尾胚胎的腹节数量较少，其中一些比正常的要大。早在受精后8小时就可以观察到突变表型，此时观察到无尾胚胎的气管小凹比野生型少。在9小时时，无尾胚胎出现缺失的A8、A9和A10节段，并具有异常的唇腭裂、视叶和头前叶。A4、A5、A6和A7片段在此阶段比野生型出现更大的无尾胚。thetailessmutation，虽然影响前和后外胚层结构的成熟胚胎，不影响极细胞的形成，后中肠，或proctodeum，从最后的区域出现的胚胎。然而，突变确实导致马氏管形成失败。与其对外胚层节段的影响一致，无尾导致腹神经索中分段配对神经节的数量减少，以及气管系统后部区域的突然改变。的作用thetailessgene可能发挥在形成的最前面和后面的地区的胚胎的外胚层体计划进行了讨论。
The recessive zygotic lethal mutationtaillessmaps to region 100A5,6-B1,2 at the tip of the right arm of chromosome 3, and results in shortened pharyngeal ridges in the head skeleton of the mature embryo and the elimination of the eighth abdominal segment and telson. Although they have a normal body length,taillessembryos have a smaller number of abdominal segments, some of which are larger than normal. The mutant phenotype is seen as early as 8 hr post-fertilization, whentaillessembryos are observed to have fewer tracheal pits than wildtype. At 9 hr,taillessembryos appear to be missing segments A8, A9, and A10 and have an abnormal clypeolabrum, optic lobes, and procephalic lobe. Segments A4, A5, A6, and A7 appear larger intaillessembryos than wildtype at this stage. Thetaillessmutation, although affecting anterior and posterior ectodermal structures in the mature embryo, does not affect the formation of pole cells, the posterior midgut, or the proctodeum, which arise from the most posterior region of the embryo. The mutation does result, however, in the failure of Malpighian tubule formation. Consistent with its effect on ectodermal segments,taillessleads to a reduction in the number of segmented, paired ganglia in the ventral nerve cord as well as to an abrupt alteration in the posterior region of the tracheal system. The role thetaillessgene may play in the formation of the most anterior and posterior regions of the embryo's ectodermal body plan is discussed.