The transmission potential of malaria-infected mosquitoes (An.gambiae-Keele, An.arabiensis-Ifakara) is altered by the vertebrate blood type they consume during parasite development.
The transmission potential of malaria-infected mosquitoes (An.gambiae-Keele, An.arabiensis-Ifakara) is altered by the vertebrate blood type they consume during parasite development.
复制标题
DOI：
10.1038/srep40520
复制
发表时间：
2017-01-17
影响因子：
4.6
通讯作者：
Ferguson HM
中科院分区：
文献类型：
--
作者：
Emami SN;Ranford-Cartwright LC;Ferguson HM
疟疾寄生虫在蚊子载体（孢子体）内发育的效率是传播的关键决定因素。孢子形成被认为受环境条件和蚊子/寄生虫遗传因素的控制，而蚊子在寄生虫发育期间的行为影响最小。为了验证这一假设，我们调查了恶性疟原虫成功产孢到人类感染传播阶段是否受到受感染蚊子赖以为生的宿主物种的影响。对两种主要的非洲病媒物种进行了研究，通常发现它们在先天宿主偏好上存在差异：阿拉伯按蚊（Anopheles arabiensis）和阿拉伯按蚊（Anopheles arabiensis）。严格意义上的冈比亚。我们表明，媒介发展传染性感染（孢子虫）的比例受到孢子形成过程中消耗的宿主血液来源的影响。这种影响的方向与媒介对宿主的先天偏好有关：通常以人类为专家的安产生了较高的孢子虫患病率。冈比亚原虫以人血为食，而与牛血相比，冈比亚原虫更嗜兽。以牛血为食后，Arabiensis的患病率显著增高。讨论了这些结果的潜在流行病学意义。
The efficiency of malaria parasite development within mosquito vectors (sporogony) is a critical determinant of transmission. Sporogony is thought to be controlled by environmental conditions and mosquito/parasite genetic factors, with minimal contribution from mosquito behaviour during the period of parasite development. We tested this assumption by investigating whether successful sporogony of Plasmodium falciparum parasites through to human-infectious transmission stages is influenced by the host species upon which infected mosquitoes feed. Studies were conducted on two major African vector species that generally are found to differ in their innate host preferences: Anopheles arabiensis and An. gambiae sensu stricto. We show that the proportion of vectors developing transmissible infections (sporozoites) was influenced by the source of host blood consumed during sporogony. The direction of this effect was associated with the innate host preference of vectors: higher sporozoite prevalences were generated in the usually human-specialist An. gambiae s.s. feeding on human compared to cow blood, whereas the more zoophilic An. arabiensis had significantly higher prevalences after feeding on cow blood. The potential epidemiological implications of these results are discussed.