CD46-MEDIATED MEASLES-VIRUS ENTRY - A FIRST KEY TO HOST-RANGE SPECIFICITY
CD46-MEDIATED MEASLES-VIRUS ENTRY - A FIRST KEY TO HOST-RANGE SPECIFICITY
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DOI：
10.1016/s0966-842x(00)88972-6
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发表时间：
1995-09-01
影响因子：
15.9
通讯作者：
DEVAUX, P
中科院分区：
文献类型：
--
作者：
GERLIER, D;VARIORKRISHNAN, G;DEVAUX, P
人类是麻疹病毒的唯一自然宿主。 CD46 作为病毒受体的鉴定以及 moesin 的参与为病毒进入细胞期间发生的分子事件提供了一些线索。了解 CD46 的关键作用为创建对麻疹病毒感染敏感的转基因小鼠铺平了道路。
Humans are the sole natural host of measles virus. The identification of CD46 as a virus receptor and of the involvement of moesin sheds some light on the molecular events occurring during virus entry into the cell. Knowledge of the key role of CD46 paves the way to creating transgenic mice sensitive to measles virus infection.