Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.
Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.
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DOI：
10.15698/mic2016.08.516
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发表时间：
2016-08
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影响因子：
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通讯作者：
Honigberg SM
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作者：
Honigberg SM
二倍体芽殖酵母（Saccharomycescerevisiae）可以通过几种可选择的分化命运之一来响应营养限制，并且这些命运中的每一种提供不同的生物学功能。当考虑到不同的菌株背景时，这些不同的命运响应于相似的环境线索而发生，由相同的信号转导途径调节，并且共享许多相同的主调节因子。我建议，命运选择，环境线索和信号通路之间的关系不是布尔型的，但涉及分级水平的信号，通路激活和主调节器活动。在环境线索之间没有大的差异的情况下，线索浓度的微小差异可能会被细胞间信号加强。这些信号对于群落内的命运决定特别重要，例如群落和生物膜，其中命运选择在群落的一个区域与另一个区域之间有很大差异。线索、信号通路、主调节器和细胞命运之间缺乏布尔关系，这可能使酵母菌群能够对它们在自然界中遇到的各种环境做出适当的反应。
Diploid budding yeast (Saccharomyces cerevisiae) can adopt one of several alternative differentiation fates in response to nutrient limitation, and each of these fates provides distinct biological functions. When different strain backgrounds are taken into account, these various fates occur in response to similar environmental cues, are regulated by the same signal transduction pathways, and share many of the same master regulators. I propose that the relationships between fate choice, environmental cues and signaling pathways are not Boolean, but involve graded levels of signals, pathway activation and master-regulator activity. In the absence of large differences between environmental cues, small differences in the concentration of cues may be reinforced by cell-to-cell signals. These signals are particularly essential for fate determination within communities, such as colonies and biofilms, where fate choice varies dramatically from one region of the community to another. The lack of Boolean relationships between cues, signaling pathways, master regulators and cell fates may allow yeast communities to respond appropriately to the wide range of environments they encounter in nature.