Atherosclerosis of the carotid artery: Evaluation by magnetic resonance angiography
Atherosclerosis of the carotid artery: Evaluation by magnetic resonance angiography
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DOI：
10.1002/jmri.1880060505
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发表时间：
1996-09-01
期刊：
影响因子：
--
通讯作者：
Strandness, DE
中科院分区：
文献类型：
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作者：
Wildy, KS;Yuan, C;Strandness, DE
颈动脉粥样硬化斑块（AP）可导致脑缺血，这一事件与狭窄程度和AP的组成相关。目前，狭窄的准确估计可以通过X射线血管造影术或三维飞行时间（TOF）磁共振血管造影术（MRA）获得。我们的目的是确定三维TOF MRA图像是否也可以提供斑块位置、形态和成分的信息。7例动脉内膜切除术前患者进行了三维TOF MRA。动脉内膜切除术后，对斑块进行组织学评价，所有病例的三维TOF MRA图像均包含足够的软组织对比度以区分斑块与周围组织。斑块形态学与组织学的相关性达80%，斑块内出血和钙化分别表现为中等强度和极低强度区域。这些初步结果表明，三维TOF MRA可用于研究颈动脉粥样硬化的发生和发展。
Carotid artery atherosclerotic plaques (APs) can lead to brain ischemia, an event shown to correlate with both the degree of stenosis and the composition of the AP. Currently, accurate estimates of stenosis can be obtained by either x-ray angiography or three-dimensional time-of-flight (TOF) magnetic resonance angiography (MRA). Our purpose was to determine whether three-dimensional TOF MRA images could also provide information on plaque location, morphology, and composition. Seven pre-endarterectomy patients underwent three-dimensional TOF MRA. After endarterectomy, plaque histology was evaluated, Three-dimensional TOF MRA images contained sufficient soft tissue contrast to differentiate the plaques from the surrounding tissues in all cases. Estimation of plaque morphology had 80% correlation with histology, finally, intraplaque hemorrhage and calcification were depicted as regions of moderately high and very low intensity, respectively, These preliminary results suggest that three-dimensional TOF MRA may be useful in studying the development and progression of carotid atherosclerosis.