Sources of variation evaluation of 24,25(OH)2D levels and the ratio of 250HD to 24,25(OH)2D in apparently healthy Chinese adults: a multicenter cross-sectional study
Sources of variation evaluation of 24,25(OH)2D levels and the ratio of 250HD to 24,25(OH)2D in apparently healthy Chinese adults: a multicenter cross-sectional study
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表观健康的中国成年人 24,25(OH)2D 水平以及 250HD 与 24,25(OH)2D 比率的变异评估来源：一项多中心横断面研究
DOI：
10.1016/j.jsbmb.2019.105407
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发表时间：
2019-09-01
影响因子：
4.1
通讯作者：
Qiu, Ling
中科院分区：
文献类型：
--
作者：
Yu, Songlin;Wang, Danchen;Qiu, Ling
24,25(OH)(2)D和250HD/24,25(OH)(2)D比值最近被证明可用于筛选由CYP24A1突变引起的高钙血症。然而，目前还没有针对中国人群的24,25(OH)(2)D的基于人群的数据，也很少有研究评估24,25(OH)(2)D水平和250HD/24,25(OH)(2)D比值的变异来源。因此，2018年，我们从中国6个代表性城市（北京、东营、贵阳、乌鲁木齐、深圳和齐齐哈尔）招募了1211名表面健康、无系统性疾病的成年人。采用同位素稀释液相色谱串联质谱法测定24,25(OH)(2)D和250HD水平。多元回归分析表明，性别对24,25(OH)(2)D、250HD和250HD/24,25(OH)(2)D的影响最大（rp分别为-0.255、-0.253和0.141），年龄对250HD的影响也最大，但对24,25(OH)(2)D和250HD/24,25(OH)(2)D的影响较小。男性的24,25(OH)(2)D和250HD水平明显高于女性，但250HD/24,25(OH)(2)D水平明显低于女性。东营个体24、25(OH)(2)D和250HD值最高，乌鲁木齐个体最低。24,25(OH)(2)D、250HD和250HD/24,25(OH)(2)D的中位值（2.5-97.5%）分别为1.2(0.36-2.65)ng/mL、18.9(8.6-32.5)ng/mL和16.0（9.8-30.8）。24,25(OH)(2)D与250HD呈显著负相关（r = 0.838, p < 0.001）， 250HD/24,25(OH)(2)D与24,25(OH)(2)D呈显著负相关（r = -0.758, p < 0.001）， 250HD呈显著负相关（r = -0.310, p < 0.001）。总之，在这项全国性、多中心、横断面研究中，我们评估了中国人群的24,25(OH)(2)D水平和250HD/24,25(OH)(2)D比率。性别对24,25(OH)(2)D、250HD和250HD/24,25(OH)(2)D的变异贡献最大。
24,25(OH)(2)D and the 250HD/24,25(OH)(2)D ratio have recently been shown to be useful for screening for hypercalcemia caused by CYP24A1 mutations. However, no population-based data on 24,25(OH)(2)D have been published for Chinese populations, and few studies evaluated the sources of variation on 24,25(OH)(2)D levels and the 250HD/24,25(OH)(2)D ratio. Hence, in 2018, we enrolled 1211 apparently healthy adults without systematic diseases from six representative cities in China (Beijing, Dongying, Guiyang, Urumqi, Shenzhen, and Qiqihar). 24,25(OH)(2)D and 250HD levels were measured using isotope dilution liquid chromatography tandem mass spectrometry. Multiple regression analysis showed that sex contributed the most to variations in 24,25(OH)(2)D, 250HD, and 250HD/24,25(OH)(2)D (rp = -0.255, -0.253, and 0.141, respectively), and age also contributed to variations in 250HD but not 24,25(OH)(2)D or 250HD/24,25(OH)(2)D. Men had significantly higher 24,25(OH)(2)D and 250HD levels than women, but had significantly lower 250HD/24,25(OH)(2)D values. Individuals from Dongying had the highest 24,25(OH)(2)D and 250HD values, whereas individuals from Urumqi had the lowest values. The median(2.5-97.5%) values for 24,25(OH)(2)D, 250HD, and 250HD/24,25(OH)(2)D were 1.2(0.36-2.65) ng/mL, 18.9(8.6-32.5) ng/mL, and 16.0 (9.8-30.8), respectively. 24,25(OH)(2)D was significantly correlated with 250HD (r = 0.838, p < 0.001), and 250HD/24,25(OH)(2)D was significantly negatively correlated with 24,25(OH)(2)D (r = -0.758, P < 0.001) and 250HD (r = -0.310, P < 0.001). In conclusion, in this nationwide, multicenter, cross-sectional study, we evaluated the levels of 24,25(OH)(2)D and the 250HD/24,25(OH)(2)D ratio in the Chinese population. Sex contributed the most to variations in 24,25(OH)(2)D, 250HD, and 250HD/24,25(OH)(2)D.