White Matter Hyperintensities Relate to Basal Ganglia Functional Connectivity and Memory Performance in aMCI and SVMCI
White Matter Hyperintensities Relate to Basal Ganglia Functional Connectivity and Memory Performance in aMCI and SVMCI
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白质高信号与 aMCI 和 SVMCI 中的基底神经节功能连接和记忆性能相关
DOI：
10.3389/fnins.2019.01204
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发表时间：
2019-11-13
影响因子：
4.3
通讯作者：
Yi, Liye
中科院分区：
文献类型：
--
作者：
Acharya, Alaka;Liang, Xia;Yi, Liye
脑小血管疾病在血管性和非血管性痴呆中起着至关重要的作用。白色高信号（WMH）是脑小血管疾病的神经影像学标志物，其位置在不同类型的痴呆症之间存在差异，基底节（BG）中的WMH与血管性认知障碍（VCI）尤其相关。然而，跨BG核的WMH的解剖变化及其对脑网络连接障碍的影响尚未清楚地阐明。研究样本包括40名遗忘型轻度认知障碍（aMCI）患者，40名皮质下血管性MCI（SVMCI）患者和40名健康对照者。我们使用T2加权磁共振成像检查WMH的体积。我们还评估了BG皮质通信的干扰，通过测量静息态功能连接（rsFC）的功能磁共振成像信号。WMH在SVMCI组中更明显，特别是在尾状核区域。在SVMCI患者中，背侧尾状核中较高的WMH与执行控制区域的FC较弱和即时回忆表现较差相关，腹侧尾状核中的WMH与前默认模式区域的FC较弱和延迟回忆表现较差相关。相比之下，在aMCI患者中，BG WMH与其功能连接变化的变化不相关，这表明几乎所有BG结构的连接性较弱，而不是如在SVMCI组中观察到的那样局限于特定的BG细分。我们的研究结果表明，不均匀分布的BG WMH仅在SVMCI患者中与功能网络相互作用和言语情景记忆表现的变化相关，这建立了血管相关结构异常，BG回路功能完整性和SVMCI情景记忆障碍之间的联系，可能反映了脑血管病变在破坏阿尔茨海默病和皮质下血管性痴呆之间的网络水平通信和认知方面的不同作用。
Cerebral small vessel diseases play a crucial role in both vascular and non-vascular dementias. The location of white matter hyperintensities (WMHs), a neuroimaging marker of cerebral small vessel disease, has been found to vary between different types of dementias, and those in the basal ganglia (BG) have been particularly associated with vascular cognitive impairment (VCI). However, anatomical variation of WMHs across BG nuclei and its effect on brain network dysconnectivity has not been clearly elucidated. The study sample consisted of 40 patients with amnestic mild cognitive impairment (aMCI), 40 with subcortical vascular MCI (SVMCI), and 40 healthy control subjects. We examined the volume of WMH using T2-weighted magnetic resonance imaging. We also assessed the disturbances in BG-cortical communication by measuring resting-state functional connectivity (rsFC) from the functional magnetic resonance imaging signal. WMHs were more pronounced in the SVMCI group particularly in the caudate regions. In SVMCI patients, while higher WMHs in the dorsal caudate correlated with weaker FC with executive control regions and worse immediate recall performance, WMHs in the ventral caudate were associated with weaker FC with anterior default mode regions and worse delayed recall performance. In contrast, in aMCI patients, BG WMHs were not correlated with their changes in functional connectivity changes, which showed weaker connectivity with almost all BG structures, rather than restricting to specific BG subdivisions as observed in the SVMCI group. Our findings demonstrate that heterogeneously distributed BG WMHs are associated with changes in functional network interactions and verbal episodic memory performance only in SVMCI patients, which establishes a link between cerebrovascular-related structural abnormality, functional integrity of BG circuits, and episodic memory impairments in SVMCI, and may reflect a differential role of the cerebrovascular pathology in disrupting network-level communications and cognition between Alzheimer’s and subcortical vascular dementia.