AN EYE-MOVEMENT DISORDER IN AMYOTROPHIC LATERAL SCLEROSIS
AN EYE-MOVEMENT DISORDER IN AMYOTROPHIC LATERAL SCLEROSIS
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DOI：
10.1212/wnl.31.10.1282
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发表时间：
1981-01-01
期刊：
影响因子：
9.9
通讯作者：
BARRON, SA
中科院分区：
文献类型：
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作者：
JACOBS, L;BOZIAN, D;BARRON, SA
在18例肌萎缩侧索硬化症患者中，有11例(61%)的EOG记录到有缺陷的追踪性眼球运动。追踪缺陷包括在正常受试者中将顺畅的追踪分解为跳视运动，这些运动严重超过了追赶的跳动中断(频率和幅度)。在9例患者中，肉眼检查和EOG均可见明显的缺陷追踪(扭动)，2例仅在EOG中可见这种异常。8例仅有眼球运动功能异常，3例EOG可见眼球跳动障碍(视动性眼球震颤或共轭凝视)。尸检发现1例有追踪性缺陷的患者黑质神经元变性和内囊脱髓鞘，而另1例无此缺陷。追踪缺陷可能是ALS中锥体外系或幕上锥体受累的征兆。
Defective pursuit eye movements were recorded by electrooculography (EOG) in 11 of 18 patients (61%) with amyotrophic lateral sclerosis [ALS]. Pursuit defects consisted of a breakdown of smooth tracking into saccadic motions that were grossly in excess (frequencies and amplitudes) of saccadic interruptions of pursuit in normal subjects. In 9 patients, defective pursuits (cogwheeling) were obvious by visual inspection and by EOG; in 2, this abnormality was seen only by EOG. In 8 patients the pursuit defect was the only abnormality of oculomotor function; in 3 there were also saccadic defects (optokinetic nystagmus or conjugate gaze) discerned by EOG. Autopsy revealed neuronal degeneration in substantia nigra and demyelination in internal capsule in 1 patient with the pursuit defect but not in another without the defect. The pursuit defect may be a sign of extrapyramidal or supratentorial pyramidal involvement in ALS.