Substance use and the adolescent brain:: A toxic combination?
Substance use and the adolescent brain:: A toxic combination?
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DOI：
10.1177/0269881107078309
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发表时间：
2007-11-01
影响因子：
4.1
通讯作者：
Hall, Wayne D.
中科院分区：
文献类型：
--
作者：
Lubman, Dan I.;Yucel, Murat;Hall, Wayne D.
早发性物质使用一直与青春期后期和成年早期一系列不良后果的风险增加有关。然而，这种关系背后的机制尚未完全理解。在发育神经科学的最新进展，以及新兴的文献早发性物质的使用，表明青少年的大脑可能更容易受到成瘾物质的影响，因为广泛的神经成熟的过程中发生在这一时期。这些发现表明，早期发病的用户的发展轨迹中断，尽管有越来越多的证据表明，高风险的青少年有发病前的神经生物学脆弱性。迫切需要进行前瞻性研究，调查早期青少年吸毒的神经生物学相关因素和后遗症，以告知适当的公共卫生对策。
Early onset substance use has consistently been associated with increased risk for a range of adverse outcomes in late adolescence and early adulthood. However, the mechanisms that underlie this relationship are not fully understood. Recent advances in developmental neuroscience, together with emerging literature on early onset substance use, suggest that the adolescent brain may be more vulnerable to the effects of addictive substances because of the extensive neuromaturational processes that are occurring during this period. Such findings are suggestive of disrupted developmental trajectories in early onset users, although there is growing evidence that high-risk youths have premorbid neurobiological vulnerabilities. Prospective studies investigating neurobiological correlates and sequelae of early adolescent drug use are urgently required to inform appropriate public health responses.