The adverse effect of spasticity on 3-month poststroke outcome using a population-based model.
The adverse effect of spasticity on 3-month poststroke outcome using a population-based model.
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DOI：
10.1155/2014/696089
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发表时间：
2014
影响因子：
1.5
通讯作者：
Kissela B
中科院分区：
文献类型：
--
作者：
Belagaje SR;Lindsell C;Moomaw CJ;Alwell K;Flaherty ML;Woo D;Dunning K;Khatri P;Adeoye O;Kleindorfer D;Broderick J;Kissela B
一些设备和药物已被用于治疗中风后痉挛。然而，痉挛对结果的影响仍然存在争议。利用460名缺血性脑卒中患者的队列数据，我们先前发表了一个经过验证的多变量回归模型，用于预测3个月修正Rankin评分（mRS）作为功能结局的指标。在这里，我们检验了是否包括痉挛改善模型拟合，并估计痉挛对结果的影响。在中风后3个月的直接访谈中，对“你中风后有过痉挛吗？”这个问题的积极回答是痉挛的定义。超过90天（n = 30）或没有可用痉挛数据（n = 102）的患者被排除在外。考虑到年龄、糖尿病、白质病变和回顾性NIHSS，痉挛影响3个月的功能状态（β = 0.420, 95 CI = 0.194 ~ 0.645）。以痉挛度为协变量，模型的r2由0.599变为0.622。在我们的模型中，在调整已知协变量后，队列中痉挛的存在与3个月mRS恶化的平均相关性为0.4。这种显著的不良影响增加了先前确定因素之外的预测价值。
Several devices and medications have been used to address poststroke spasticity. Yet, spasticity's impact on outcomes remains controversial. Using data from a cohort of 460 ischemic stroke patients, we previously published a validated multivariable regression model for predicting 3-month modified Rankin Score (mRS) as an indicator of functional outcome. Here, we tested whether including spasticity improved model fit and estimated the effect spasticity had on the outcome. Spasticity was defined by a positive response to the question “Did you have spasticity following your stroke?” on direct interview at 3 months from stroke onset. Patients who had expired by 90 days (n = 30) or did not have spasticity data available (n = 102) were excluded. Spasticity affected the 3-month functional status (β = 0.420, 95 CI = 0.194 to 0.645) after accounting for age, diabetes, leukoaraiosis, and retrospective NIHSS. Using spasticity as a covariable, the model's R 2 changed from 0.599 to 0.622. In our model, the presence of spasticity in the cohort was associated with a worsened 3-month mRS by an average of 0.4 after adjusting for known covariables. This significant adverse effect on functional outcomes adds predictive value beyond previously established factors.
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影响因子：
3
作者：
Leathley, MJ;Gregson, JM;Watkins, CL
通讯作者：
Watkins, CL
影响因子：
5.1
作者：
Welmer, A. -K.;Holmqvist, L. Widen;Sommerfeld, D. K.
通讯作者：
Sommerfeld, D. K.
影响因子：
2.9
作者：
Welmer, AK;von Arbin, M;Sommerfeld, DK
通讯作者：
Sommerfeld, DK
影响因子：
11
作者：
Bhakta, BB;Cozens, JA;Bamford, JM
通讯作者：
Bamford, JM
影响因子：
5.1
作者：
Lundstrom, E.;Terent, A.;Borg, J.
通讯作者：
Borg, J.