From isolated to networked: a paradigmatic shift in mitochondrial physiology.

From isolated to networked: a paradigmatic shift in mitochondrial physiology.
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DOI:
10.3389/fphys.2010.00020
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发表时间:
2010
影响因子:
4
通讯作者:
Aon MA
Aon MA
中科院分区:
医学2区
文献类型:
--
作者:
Aon MA

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A new paradigm of mitochondrial function in networks is emerging which includes, without undermining, the glorious and still useful paradigm of the isolated mitochondrion. The mitochondrial network paradigm introduces new concepts, tools, and analytical techniques. Among them is that mitochondrial function in networks exhibits interdependence and multiplicative effects based on synchronization mechanisms, which involve communication between mitochondrial neighbors. The collective dynamics of these networks become advantageous for coordinating function spanning from the cell, to the tissue, and the organ. However, under severely stressful conditions the network behavior of mitochondria may become life threatening.
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