Straightening up is required to nucleate new microtubules.
Straightening up is required to nucleate new microtubules.
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DOI:
10.1083/jcb.202102123
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发表时间:
2021-04-05
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影响因子:
--
通讯作者:
Gardner MK
中科院分区:
文献类型:
--
作者:
Gardner MK
Gardner highlights work from Ayukawa et al. that reveals that microtubule oligomer curvature, rather than length, is the limiting factor that slows the microtubule nucleation rate. In this issue, Ayukawa, Iwata, Imai, and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202007033) use rapid temporal and high-spatial-resolution electron microscopy imaging to examine the earliest stages of new microtubule nucleation. They discover that straightening of curved tubulin oligomers increases the efficiency of microtubule nucleation.
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