Straightening up is required to nucleate new microtubules.

Straightening up is required to nucleate new microtubules.
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DOI:
10.1083/jcb.202102123
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发表时间:
2021-04-05
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Gardner MK
Gardner MK
中科院分区:
其他
文献类型:
--
作者:
Gardner MK

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Gardner强调了Ayukawa等人的工作,该工作揭示了微管寡聚体曲率而不是长度是减缓微管成核速率的限制因素。本期,Ayukawa、岩田、今井及其同事(2021. J. Cell Biol. https://doi.org/10.1083/jcb.202007033)使用快速时间和高空间分辨率电子显微镜成像来检查新微管成核的最早阶段。他们发现弯曲的微管蛋白寡聚体的拉直增加了微管成核的效率。
Gardner highlights work from Ayukawa et al. that reveals that microtubule oligomer curvature, rather than length, is the limiting factor that slows the microtubule nucleation rate. In this issue, Ayukawa, Iwata, Imai, and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202007033) use rapid temporal and high-spatial-resolution electron microscopy imaging to examine the earliest stages of new microtubule nucleation. They discover that straightening of curved tubulin oligomers increases the efficiency of microtubule nucleation.
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