Strain differences in susceptibility to the teratogenic effect of acetazolamide in mice.
Strain differences in susceptibility to the teratogenic effect of acetazolamide in mice.
复制标题
小鼠中乙酰唑胺致畸作用敏感性的品系差异。
DOI：
10.1002/tera.1420080205
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
T. Maren
中科院分区：
文献类型：
--
作者：
M. C. Green;C. A. Azar;T. Maren
妊娠雌性小鼠在妊娠第9天或第10天腹腔注射乙酰唑胺（750 mg/kg两次给药，上午10点和下午4点）导致前肢轴后异常，在CBA/J和C57 BL/6 J品系中频率较高，在A/J和DBA/2 J中频率中等，在C3 H/HeJ和SWR/J中频率较低。CBA/J在第10天对给药最敏感，A/J在第9天和第10天，C57 BL/6 J和C3 H/HeJ在第9天。最后一次注射后4 h羊水量无减少。
Intraperitoneal administration of acetazolamide to pregnant female mice on day 9 or 10 of gestation (750 mg/kg given twice, at 10 AM and 4 PM) produced postaxial abnormalities of the forelimbs with high frequency in the CBA/J and C57BL/6J strains, intermediate frequency in A/J and DBA/2J, and low frequency in C3H/HeJ and SWR/J. CBA/J was most susceptible to treatment on day 10, A/J on days 9 and 10, and C57BL/6J and C3H/HeJ on day 9. There was no reduction in amount of amniotic fluid 4 h after the last injection.