Synthesis and study of anti-HIV-1 RT activity of 5-benzoyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one derivatives
Synthesis and study of anti-HIV-1 RT activity of 5-benzoyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one derivatives
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5-苯甲酰基-4-甲基-1,3,4,5-四氢-2H-1,5-苯二氮卓-2-酮衍生物的合成及抗HIV-1 RT活性研究
DOI：
10.1016/j.bioorg.2017.03.013
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发表时间：
2017-06-01
影响因子：
5.1
通讯作者：
Sankaranarayanan, Murugesan
中科院分区：
文献类型：
--
作者：
Chander, Subhash;Tang, Cheng-Run;Sankaranarayanan, Murugesan
本论文设计、合成了14个5-苯甲酰基-4-甲基-1，3，4，5-四氢-2H-1，5-苯并二氮杂卓-2-酮衍生物，并对其进行了光谱表征。此外，使用基于ELISA的比色测定法对标题化合物进行了针对野生型HIV-1 RT酶的体外筛选，其中四个化合物显著抑制RT活性，IC 50
In the present study, a series of fourteen 5-benzoyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one derivatives were designed, synthesized and characterized by appropriate spectral analysis. Further, titled compounds were in-vitro screened against wild HIV-1 RT enzyme using ELISA based colorimetric assay, in which four compounds significantly inhibited the RT activity with IC50