The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome
The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome
复制标题
鱼油脂肪乳对短肠综合征大鼠模型肠衰竭相关肝病的保护作用
DOI：
10.1007/s00383-017-4190-4
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发表时间：
2017
影响因子：
1.8
通讯作者：
Ieiri Satoshi
中科院分区：
文献类型：
--
作者：
Machigashira Seiro;Kaji Tatsuru;Onishi Shun;Yamada Waka;Yano Keisuke;Yamada Koji;Masuya Ryuta;Kawano Takafumi;Nakame Kazuhiko;Mukai Motoi;Ieiri Satoshi
目的小儿肠衰竭需要长期肠外营养（PN），但这种营养支持会引起肝功能障碍，如肠衰竭相关性肝病（IFALD）。多项研究表明，大豆油（SO）产生的脂肪乳剂与IFALD的发生有关。方法SD大鼠颈静脉置管，随机分为3组：假手术组（Sham组）、80%小肠切除（80% SBR）+ TPN + SO脂肪乳剂组（SO组）和80% SBR + TPN + FO脂肪乳剂组（FO组）。所有大鼠均被安乐死，血清生化和肝组织学analysed.ResultsNo显着差异，血清肝或胆酶之间的SO和FO组。FO组的病理结果和NAFLD评分未显示脂肪变性，且显著低于SO组。在SO和FO组的脂肪酸谱的分析并没有表明必需脂肪酸缺乏症（EFAD）。结论FO脂肪乳剂可能有对脂肪变性的IFALD没有EFAD的保护作用。
PurposePediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis.MethodsSprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group). All rats were euthanized and the serum biochemistry and hepatic histology analyzed.ResultsNo significant differences in the serum liver or biliary enzymes were noted between the SO and FO groups. The pathological findings and NAFLD score in the FO group did not show steatosis and were significantly lower than in the SO group. An analysis of the fatty acids profile in the both the SO and FO groups did not indicate essential fatty acid deficiency (EFAD).ConclusionFO lipid emulsion may have a protective role against steatosis of IFALD without EFAD.