Sleep Duration and Risk for Hypertension in Women: Results from The Nurses Health Study
Sleep Duration and Risk for Hypertension in Women: Results from The Nurses Health Study
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DOI：
10.1093/ajh/hpt044
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发表时间：
2013-07-01
影响因子：
3.2
通讯作者：
Forman, John P.
中科院分区：
文献类型：
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作者：
Gangwisch, James E.;Feskanich, Diane;Forman, John P.
急性睡眠限制已被证明会增加血压和交感神经系统活动。我们调查了1986年自我报告睡眠时间的妇女的睡眠时间与高血压的关系（82，130）和2000年（n 71，658）在护士健康研究I（NHS-I）和2001年（n 84，674）在护士健康研究II（NHS-II）中。在逻辑回归模型中控制多个危险因素后，在所有3组中，每晚睡眠时间为5小时的妇女的高血压患病率显著高于睡眠时间为7小时的妇女（比值比1.19，95%可信区间[CI] 1.14 ± 1.25）。在使用考克斯回归的前瞻性分析中，每晚睡眠时间少于5小时与高血压的发生率仅在年轻女性中显著相关（年龄< 50岁的风险比[HR] 1.20，95% CI 1.091.31;年龄50 - 59岁的风险比[HR] 1.11，95% CI 1.001.23）。在普遍分析和事件分析中，结果与肥胖作为部分媒介的情况一致。结果与糖尿病或高胆固醇血症作为介质或轮班工作，打鼾，更年期，或绝经后激素治疗作为效应modifiers. Enough睡眠可能代表一种生活方式的做法值得调查的方法，以减少高血压的发病率和患病率。
Acute sleep restriction has been shown to increase blood pressure and sympathetic nervous system activity.We investigated the relationships between sleep duration and hypertension among women whose sleep durations were self-reported in 1986 (n 82,130) and 2000 (n 71,658) in the Nurses Health Study I (NHS-I) and in 2001 (n 84,674) in the Nurses Health Study II (NHS-II).After controlling for multiple risk factors in logistic regression models, the prevalence of hypertension was significantly higher among women in all 3 groups who slept 5 hours (odds ratio 1.19, 95% confidence interval [CI] 1.141.25) per night compared with 7 hours. In prospective analyses using Cox regression shorter sleep duration of 5 hours per night was significantly associated with a higher incidence of hypertension only in younger women (hazard ratio [HR] 1.20, 95% CI 1.091.31 for those aged < 50 years; HR 1.11, 95% CI 1.001.23 for those aged 5059 years). In both prevalent and incident analyses, results were consistent with obesity acting as a partial mediator. Results were not consistent with diabetes or hypercholesterolemia acting as mediators or with shift work, snoring, menopause, or postmenopausal hormone therapy acting as effect modifiers.Sufficient sleep could represent a lifestyle practice worthy of investigation as an approach to reduce hypertension incidence and prevalence.