The phosphatidylinositol 4-kinases: don't call it a comeback.
The phosphatidylinositol 4-kinases: don't call it a comeback.
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DOI：
10.1007/978-94-007-3012-0_1
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Waugh, Mark G
中科院分区：
文献类型：
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作者：
Minogue, Shane;Waugh, Mark G
磷脂酰肌醇4-磷酸（PtdIns4P）是一种数量较少的膜磷脂，是经典激动剂调节的磷脂酶C信号通路中PtdIns(4,5)P(2)的前体。然而，PtdIns4P也控制着许多运输分子的招募和功能，主要是在高尔基复合体中。在肌醇头群的D4位置磷酸化的磷酸肌苷（pi）大部分来自PtdIns4P，并在多种基本细胞过程中发挥作用，包括分泌、细胞迁移、凋亡和有丝分裂发生；因此，PtdIns4P的生物合成可以被认为是许多pi依赖过程的关键调控点。两个结构不同的序列家族，II型和III型PtdIns4P激酶，在真核生物中负责PtdIns4P的合成。这些重要的蛋白质通过不同的机制进行差异表达、定位和调节，表明这些酶在运输和信号传导中发挥着非冗余的作用。近年来，我们对PtdIns4K生物学的理解取得了重大进展，在这里我们总结了PtdIns4K的结构、功能和调控的最新知识。
Phosphatidylinositol 4-phosphate (PtdIns4P) is a quantitatively minor membrane phospholipid which is the precursor of PtdIns(4,5)P (2) in the classical agonist-regulated phospholipase C signalling pathway. However, PtdIns4P also governs the recruitment and function of numerous trafficking molecules, principally in the Golgi complex. The majority of phosphoinositides (PIs) phosphorylated at the D4 position of the inositol headgroup are derived from PtdIns4P and play roles in a diverse array of fundamental cellular processes including secretion, cell migration, apoptosis and mitogenesis; therefore, PtdIns4P biosynthesis can be regarded as key point of regulation in many PI-dependent processes.Two structurally distinct sequence families, the type II and type III PtdIns 4-kinases, are responsible for PtdIns4P synthesis in eukaryotic organisms. These important proteins are differentially expressed, localised and regulated by distinct mechanisms, indicating that the enzymes perform non-redundant roles in trafficking and signalling. In recent years, major advances have been made in our understanding of PtdIns4K biology and here we summarise current knowledge of PtdIns4K structure, function and regulation.