Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode
Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode
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DOI：
10.1016/s0920-9964(03)00056-2
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发表时间：
2003-12-15
影响因子：
4.5
通讯作者：
Davidson, M
中科院分区：
文献类型：
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作者：
Caspi, A;Reichenberg, A;Davidson, M
背景：这项历史性前瞻性研究的目的是在同一受试者中追踪精神分裂症患者从病前到首次精神病发作后不久的认知损害。方法：44例首发精神分裂症患者作为研究对象。他们的认知表现作为以色列征兵委员会能力评估的一部分在16-17岁时进行了评估，当时所有人都被发现精神健康状况良好(第一次评估)，并在第一次精神病发作(第二次评估)表现出来后再次进行评估。44名健康对照也被纳入，并在与患者相同的年龄进行了两次测试。这两次的评估都包括四个分测试，分别评估抽象推理(瑞文递进矩阵-R)、思维速度和注意力(OTIS-R)、语言推理(相似性-R)和数学能力(Axithmetic-R)。结果：组内分析显示，在精神分裂症患者的第一次和第二次评估之间，在任何衡量标准上都没有统计学上的显著变化。然而，组间变化的比较显示，与健康对照组相比，精神分裂症患者的RPM-R(p=0.021)和OTIS-R(p=0.00)恶化(p
Background: The purpose of this historical prospective study was to follow the cognitive impairment in schizophrenia from the premorbid period until shortly after the onset of the first psychotic episode within the same subjects. Methods: Forty-four first episode schizophrenia patients were enrolled in the study. Their cognitive performance was assessed as part of the Israeli Draft Board aptitude assessments at ages 16-17, when all were found to be in good mental health (first assessment) and again, following the manifestation of the first psychotic episode (second assessment). Forty-four healthy comparisons were also enrolled and tested twice, at the same ages as the patients. Both times, the assessments included four subtests assessing abstract reasoning (Raven Progressive Matrices-R), mental speed and concentration (Otis-R), verbal reasoning (Similarities-R), and mathematical abilities (Axithmetic-R). Results: A within group analysis did not reveal statistically significant changes between the first and the second assessment among the schizophrenia patients on any measure. However, a between group comparison of changes showed that relative to the healthy comparisons, schizophrenia patients deteriorated on the RPM-R (p=0.021) and Otis-R (p