Role of high-, low- and very low-density lipoproteins in the transport and tumor-delivery of hematoporphyrin in vivo.
Role of high-, low- and very low-density lipoproteins in the transport and tumor-delivery of hematoporphyrin in vivo.
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DOI：
10.1016/0304-3835(86)90112-6
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发表时间：
1986-08
期刊：
影响因子：
9.7
通讯作者：
A. Barel;G. Jori;A. Perin;P. Romandini;Antonio Pagnan;S. Biffanti
中科院分区：
文献类型：
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作者：
A. Barel;G. Jori;A. Perin;P. Romandini;Antonio Pagnan;S. Biffanti
对健康家兔静脉注射游离血卟啉（1-28 mg/kg体重），血浆中3种主要脂蛋白组分（VLDL、LDL和HDL）以不同的效率结合血卟啉。将体外制备的血卟啉（Hp）与从小鼠血清中分离的脂蛋白组分的复合物经心内注射到患有MS-2纤维肉瘤的小鼠中（每千克体重1毫克Hp）。与HDL、VLDL或游离Hp相比，LDL似乎允许更特异性地将复合的Hp递送至肿瘤组织。本文还讨论了VLDL、LDL和HDL作为Hp载体在体内的不同行为。
Free hematoporphyrin administered intravenously to healthy rabbits (1–28 mg/kg body weight) is bound by the 3 major lipoprotein components of plasma (VLDL, LDL and HDL) with different efficiency. In vitro-prepared complexes of hematoporphyrin (Hp) with lipoprotein fractions isolated from mouse serum have been injected intracardiacally into mice affected by MS-2 fibrosarcoma (1 mg of Hp per kg body weight). LDL appear to allow a more specific delivery of the complexed Hp to the tumor tissue as compared with HDL, VLDL or free Hp. The different behavior of VLDL, LDL and HDL as carriers of Hp in vivo is also discussed.