Diet Quality Is Associated with Cardiometabolic Outcomes in Survivors of Childhood Leukemia
Diet Quality Is Associated with Cardiometabolic Outcomes in Survivors of Childhood Leukemia
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DOI：
10.3390/nu12072137
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发表时间：
2020-07-01
期刊：
影响因子：
5.9
通讯作者：
Marcil, Valerie
中科院分区：
文献类型：
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作者：
Berard, Sophie;Morel, Sophia;Marcil, Valerie
关于饮食如何影响儿童急性淋巴细胞白血病 (cALL) 幸存者健康的信息很少。本研究探讨了 cALL 幸存者的饮食质量指数、心脏代谢健康指标和炎症生物标志物之间的关联。参与者是 PETALE 研究的一部分（n = 241，中位年龄：21.7 岁）。计算了对 6 项饮食的遵守情况评分和超加工食品的热量摄入量。进行了多变量 Logistic 回归、Student 测试和 Mann-Whitney 测试。我们发现，根据 HEI-2015 评分，88% 的成人和 46% 的儿童对地中海饮食的遵守情况较差，36.9% 的人对世界卫生组织 (WHO) 的建议遵守情况较差，76.3% 的人的饮食习惯有待改进。平均而言，超加工食品占总能量摄入的51%。低 HDL-C 与炎症性饮食（E-DIITM 评分）和超加工食品摄入量较高有关。较高的 E-DII 评分与胰岛素抵抗 (HOMA-IR) 升高相关，食用超加工食品与高甘油三酯相关。 TNF-α、脂联素和 IL-6 的循环水平受饮食质量指数影响，而 CRP 和瘦素则不受影响。总之，cALL 幸存者对饮食建议的依从性较差，这对他们的心脏代谢健康产生了不利影响。
There is little information about how diet influences the health of childhood acute lymphoblastic leukemia (cALL) survivors. This study explores the associations between diet quality indices, cardiometabolic health indicators and inflammatory biomarkers among cALL survivors. Participants were part of the PETALE study (n= 241, median age: 21.7 years). Adherence to 6 dietary scores and caloric intake from ultra-processed foods were calculated. Multivariate logistirac regressions, Studentt-tests and Mann-Whitney tests were performed. We found that 88% of adults and 46% of children adhered poorly to the Mediterranean diet, 36.9% had poor adherence to the World Health Organisation (WHO) recommendations and 76.3% had a diet to be improved according to the HEI-2015 score. On average, ultra-processed foods accounted for 51% of total energy intake. Low HDL-C was associated with a more inflammatory diet (E-DIITM score) and higher intake of ultra-processed foods. A greater E-DII score was associated with elevated insulin resistance (HOMA-IR), and consumption of ultra-processed foods was correlated with high triglycerides. Circulating levels of TNF-alpha, adiponectin and IL-6 were influenced by diet quality indices, while CRP and leptin were not. In conclusion, survivors of cALL have poor adherence to dietary recommendations, adversely affecting their cardiometabolic health.