Unilateral whisker clipping exacerbates ethanol-induced social and somatosensory behavioral deficits in a sex- and age-dependent manner.
Unilateral whisker clipping exacerbates ethanol-induced social and somatosensory behavioral deficits in a sex- and age-dependent manner.
复制标题
单侧胡须修剪会以性别和年龄依赖性方式加剧乙醇引起的社交和体感行为缺陷。
DOI：
10.1016/j.physbeh.2014.09.002
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发表时间：
2015
影响因子：
2.9
通讯作者：
Mooney,SandraM
中科院分区：
文献类型：
--
作者：
Wellmann,KristenA;Mooney,SandraM
产前接触乙醇会导致动物和临床群体的感觉缺陷和社会互动改变。感觉刺激作为重要的线索和形状的感觉发展;发展暴露于乙醇或感觉兴奋会损害体感发育，但其对行为结果的综合影响是未知的。我们假设：1）长期产前乙醇暴露会破坏青春期的社会互动和体感表现，2）轻度感觉缺失（新生儿单侧胡须修剪; WC）会对这些行为结果产生轻度损害阈下效应，3）WC会加剧乙醇的影响。Long-Evans母鼠在妊娠期（G）6-G21天喂食含乙醇的流质饮食或成对喂食非乙醇饮食。还包括饲料喂养的对照动物。每窝1只雄性和雌性幼仔在出生后第1天（P）、P3和P5接受WC。未夹闭对照品。后代在P28或P42进行社会性互动，在P31或P42进行间隙穿越（GC）。无论年龄或性别，暴露于乙醇的幼犬比对照幼犬玩得更少，跨越的距离更短。WC进一步加剧了乙醇诱导的发挥战斗和GC赤字的所有男性，但只有在28日龄的女性。WC单独减少嗅在所有男性和年轻女性。因此，产前乙醇暴露诱导赤字的社会交往和体感性能在青春期。感官刺激加剧了乙醇对28日龄雄性和雌性动物以及42日龄雄性动物的影响，这表明乙醇暴露后代的结果具有性别和年龄依赖性变化。
Prenatal exposure to ethanol results in sensory deficits and altered social interactions in animal and clinical populations. Sensory stimuli serve as important cues and shape sensory development; developmental exposure to ethanol or sensory impoverishment can impair somatosensory development, but their combined effects on behavioral outcomes are unknown. We hypothesized 1) that chronic prenatal ethanol exposure would disrupt social interaction and somatosensory performance during adolescence, 2) that a mild sensory impoverishment (neonatal unilateral whisker clipping; WC) would have a mildly impairing to sub-threshold effect on these behavioral outcomes, and 3) that the effect of ethanol would be exacerbated by WC. Long–Evans dams were fed a liquid diet containing ethanol or pair-fed with a non-ethanol diet on gestational days (G) 6–G21. Chow-fed control animals were also included. One male and female pup per litter underwent WC on postnatal day (P)1, P3, and P5. Controls were unclipped. Offspring underwent social interaction on P28 or P42, and gap-crossing (GC) on P31 or P42. Ethanol-exposed pups played less and crossed shorter gaps than control pups regardless of age or sex. WC further exacerbated ethanol-induced play fighting and GC deficits in all males but only in 28-day-old females. WC alone reduced sniffing in all males and in younger females. Thus, prenatal ethanol exposure induced deficits in social interaction and somatosensory performance during adolescence. Sensory impoverishment exacerbates ethanol's effect in 28-day-old male and female animals and in 42-day-old males, suggesting sex- and age-dependent changes in outcomes in ethanol-exposed offspring.