CHROMOSOMAL DAMAGE IN HUMAN LEUKOCYTES INDUCED BY LYSERGIC ACID DIETHYLAMIDE
CHROMOSOMAL DAMAGE IN HUMAN LEUKOCYTES INDUCED BY LYSERGIC ACID DIETHYLAMIDE
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DOI：
10.1126/science.155.3768.1417
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发表时间：
1967-01-01
期刊：
影响因子：
56.9
通讯作者：
BACK, N
中科院分区：
文献类型：
--
作者：
COHEN, MM;MARINELLO, MJ;BACK, N
在培养的人白细胞中添加麦角酸二乙胺导致染色体异常的显著增加。染色体断裂的分布明显偏离随机，在1号染色体上积累了畸变。对一名接受该药物广泛治疗超过4年的偏执型精神分裂症患者的细胞遗传学调查显示，染色体损伤也有类似的增加。
Addition of lysergic acid diethylamide to cultured human leukocytes resulted in a marked increase of chromosomal abnormalities. The distribution of chromosome breaks deviated significantly from random, with an accumulation of aberrations in chromosome No. 1. Cytogenetic investigation of a patient extensively treated with this drug over a 4-year period for paranoid schizophrenia showed a similar increase in chromosomal damage.