Optical coherence tomography--near infrared spectroscopy system and catheter for intravascular imaging.
Optical coherence tomography--near infrared spectroscopy system and catheter for intravascular imaging.
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DOI：
10.1364/oe.21.030849
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发表时间：
2013-12-16
期刊：
影响因子：
3.8
通讯作者：
Tearney, Guillermo J
中科院分区：
文献类型：
--
作者：
Fard, Ali M;Vacas-Jacques, Paulino;Tearney, Guillermo J
由于其优越的分辨率，血管内光学相干断层扫描（IVOCT）是一种很有前途的冠状动脉壁微观结构成像工具。然而，IVOCT不能识别组织中的化学物质和分子，这是更全面地了解和准确诊断冠状动脉疾病所必需的。在这里，我们提出了一种双模成像系统和导管，它独特地将IVOCT与漫射近红外光谱（NIRS）结合在一个双模成像设备中，同时获取微观结构和成分信息。作为概念验证演示，该设备已用于可视化从患病尸体人类冠状动脉获得的显微结构和光谱信息。
Owing to its superior resolution, intravascular optical coherence tomography (IVOCT) is a promising tool for imaging the microstructure of coronary artery walls. However, IVOCT does not identify chemicals and molecules in the tissue, which is required for a more complete understanding and accurate diagnosis of coronary disease. Here we present a dual-modality imaging system and catheter that uniquely combines IVOCT with diffuse near-infrared spectroscopy (NIRS) in a single dual-modality imaging device for simultaneous acquisition of microstructural and compositional information. As a proof-of-concept demonstration, the device has been used to visualize co-incident microstructural and spectroscopic information obtained from a diseased cadaver human coronary artery.