Interaction of neuropeptides with human mast cells.
Interaction of neuropeptides with human mast cells.
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神经肽与人类肥大细胞的相互作用。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
C. Benyon
中科院分区：
文献类型：
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作者：
M. Church;M. Lowman;C. Robinson;S. Holgate;C. Benyon
人皮肤的肥大细胞，而不是肺、腺样体、扁桃体或肠的肥大细胞，对P物质、血管活性肠多肽和生长抑素有反应而释放组胺。皮肤肥大细胞的P物质受体不是平滑肌细胞的NK-1、NK-2或NK-3亚型。肽释放的时间过程和钙依赖性与抗IgE不同。对于抗-IgE，皮肤肥大细胞产生的组胺：PGD 2：LTC 4的摩尔比为1，000：25：2，而对于P物质，这些比例为1，000：1：0.1。其他神经肽也得到了类似的结果。肽刺激皮肤肥大细胞组胺释放的能力表明了一种机制，即它们从真皮神经末梢的释放与微血管系统的变化相关联。
Mast cells of human skin, but not lung, adenoids, tonsils, or intestine, release histamine in response to substance P, vasoactive intestinal polypeptide, and somatostatin. The substance P receptor of skin mast cells is not of the NK-1, NK-2 or NK-3 subtypes of smooth muscle. Time course and calcium dependency of release by peptides differed from anti-IgE. With anti-IgE, the molar ratios of histamine:PGD2:LTC4 generated by skin mast cells was 1,000:25:2, whereas with substance P these ratios were 1,000:1:0.1. Similar results were obtained with the other neuropeptides. The ability of peptides to stimulate skin mast cell histamine release suggests a mechanism whereby their release from dermal nerve endings is coupled to changes in microvasculature.