Comparison of CT methods for determining the fat content of the liver
Comparison of CT methods for determining the fat content of the liver
复制标题
DOI：
10.2214/ajr.06.0992
复制
发表时间：
2007-05-01
影响因子：
5
通讯作者：
Charnsangavej, Chusilp
中科院分区：
文献类型：
--
作者：
Kodama, Yoshihisa;Ng, Chaan S.;Charnsangavej, Chusilp
目标。本研究的目的是评估在CT扫描上测量衰减的几种方法中哪一种最适合预测肝脏脂肪含量。材料和方法。这项回溯性研究得到了我们的机构审查委员会的批准。连续登记的因转移性疾病而接受肝切除的患者组成研究组。在平扫和门脉增强的肝脏CT图像上，对12个感兴趣的肝脏区域和3个脾的感兴趣区进行了密度测量。对有无脾归一化的肝脏衰减测量结果进行分析。正常化包括肝和脾衰减值之间的差异和比率。病理脂肪含量按切除标本的非肿瘤性肝实质的百分比进行半定量分级。将肝脏的平均衰减值与病理脂肪含量、肝脾衰减值的差值和比值进行比较。结果：对88例患者的资料进行了分析。在平扫和增强CT图像上，病理性脂肪含量和衰减测量之间的所有相关性都是显著的(p<；0.0001)。平扫所有序列的R-2值均明显高于增强扫描。平扫(0.646-0.649；0.523，0.565)和增强(0.516>；0.242，0.344)CT上，仅测量肝脏密度的R-2值均高于经脾归一化的肝脏值。结论：仅在平扫CT上测量肝脏密度是预测病理脂肪含量的最佳方法。
OBJECTIVE. The purpose of this study was to assess which of a number of methods of measuring attenuation on CT scans is best for prediction of hepatic fat content.MATERIALS AND METHODS. This retrospective study was approved by our institutional review board. Consecutively registered patients who underwent liver resection for metastatic disease formed the study group. Attenuation measurements were obtained from 12 regions of interest in the liver and three in the spleen on both unenhanced and portal phase contrast-enhanced preoperative hepatic CT images. Hepatic attenuation measurements were analyzed both with and without normalization with the spleen. Normalization included both differences and ratios between hepatic and splenic attenuation values. Pathologic fat content was graded semiquantitatively as a percentage of the nonneoplastic liver parenchyma of the resected specimen. Average attenuation values of the liver were compared with pathologic fat content, as were the differences and ratios between hepatic and splenic attenuation values. Linear regression analysis was conducted on a log-log scale.RESULTS. Data on 88 patients were analyzed. On unenhanced and contrast-enhanced CT images, all associations between pathologic fat content and attenuation measurements were significant ( p < 0.0001). All series of R-2 values for unenhanced CT scans were much higher than those for contrast-enhanced CT scans. The R-2 values of liver-only measurement were higher than those of hepatic values normalized with splenic values on both unenhanced (0.646 - 0.649 > 0.523, 0.565) and contrast-enhanced ( 0.516 > 0.242, 0.344) CT.CONCLUSION. Measurement of attenuation of liver only on unenhanced CT scans is best for prediction of pathologic fat content.