Homocysteine and cellular fibronectin are increased in preeclampsia, not transient hypertension of pregnancy.
Homocysteine and cellular fibronectin are increased in preeclampsia, not transient hypertension of pregnancy.
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同型半胱氨酸和细胞纤连蛋白在先兆子痫中升高，而非妊娠期短暂性高血压。
DOI：
10.1081/prg-100104173
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Roberts,JM
中科院分区：
文献类型：
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作者：
Powers,RW;Evans,RW;Ness,RB;Crombleholme,WR;Roberts,JM
目标。本研究的目的是确认子痫前期存在内皮功能障碍，而妊娠期短暂性高血压不存在内皮功能障碍，并确定心血管危险因素同型半胱氨酸是否与内皮功能障碍的程度有关。我们测量了17例子痫前期妇女（血压升高、蛋白尿和高尿酸血症）、16例妊娠期短暂性高血压妇女（血压升高）和34例正常孕妇在入院和分娩时收集的样本中的细胞纤维连接蛋白（作为内皮损伤的标志）和血浆总同型半胱氨酸。每个先兆子痫患者通过孕前体重指数、种族和分娩时的胎龄与一名短暂性妊娠高血压患者和两名对照组进行匹配。子痫前期妇女细胞纤维连接蛋白水平明显高于妊娠期短暂性高血压和正常孕妇（分别为22.9±14.1 μg/mL和10.9±5.4和10.1±6.2 μg/mL, p<0.0001）。子痫前期妇女血浆同型半胱氨酸总水平也明显高于妊娠期短暂性高血压和正常孕妇（分别为8.3±2.5 μ μ vs 5.5±2.2和5.4±3.4 μ μM,p<0.01）。然而，与我们的假设相反，细胞纤维连接蛋白和同型半胱氨酸之间没有明显的联系。在子痫前期观察到的同型半胱氨酸浓度升高并不是所有妊娠高血压并发症的普遍特征。此外，内皮功能障碍存在于子痫前期，而在妊娠期短暂性高血压中不明显。然而，子痫前期明显的内皮功能障碍不能用观察到的同型半胱氨酸浓度升高来解释。
Objective. The objective of this study was to confirm that endothelial dysfunction is present in preeclampsia and absent in transient hypertension of pregnancy, and to determine whether the cardiovascular risk factor homocysteine is associated with the degree of endothelial dysfunction.Methods. We measured cellular fibronectin (as a marker of endothelial injury) and total plasma homocysteine in samples collected at the time of admittance to labor and delivery in 17 women with preeclampsia (increased blood pressure, proteinuria, and hyperuricemia), 16 women with transient hypertension of pregnancy (only increased blood pressure), and 34 normal pregnant women. Each subject with preeclampsia was matched by prepregnancy body mass index, race, and gestational age at delivery to one subject with transient hypertension of pregnancy and two controls.Results. Cellular fibronectin was found to be significantly increased in women with preeclampsia compared to subjects with transient hypertension of pregnancy or normal pregnant women (22.9±14.1 μg/mL versus 10.9±5.4 and 10.1±6.2 μg/mL, respectively,p<0.0001). Similarly, total plasma homocysteine was also significantly increased in the women with preeclampsia compared to subjects with transient hypertension of pregnancy or normal pregnant women (8.3±2.5 μMversus 5.5±2.2 and 5.4±3.4 μM respectively,p<0.01). However, contrary to our hypothesis, there was no apparent association between cellular fibronectin and homocysteine.Conclusions. The increased concentrations of homocysteine observed in preeclampsia are not a general feature of all hypertensive complications of pregnancy. Furthermore, endothelial dysfunction is present in preeclampsia and is not evident in transient hypertension of pregnancy. However, the apparent endothelial dysfunction in preeclampsia is not explained by the increase in homocysteine concentrations observed.