Hibernating myocardium: is the program to survive a pathway to failure?
Hibernating myocardium: is the program to survive a pathway to failure?
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冬眠的心肌：生存程序是否会走向失败？
DOI：
10.1161/circresaha.107.168278
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发表时间：
2008
影响因子：
20.1
通讯作者：
McFalls,EdwardO
中科院分区：
文献类型：
--
作者：
Kelly,RosemaryF;Sluiter,Wim;McFalls,EdwardO
冬眠承载着春天恢复活力的希望。以类似的方式，心肌“冬眠”描述了一种临床现象，即缺血性左心功能不全的患者在搭桥手术后心功能得到改善。1心肌冬眠的特征是血流减少并保留葡萄糖摄取，如正电子发射断层成像所示，并确定可能受益于血运重建的缺血性心肌病患者。2在冬眠心肌实验模型中，在没有活动性缺血的情况下，氧耗量减少。3、4这表明冬眠是一种平衡心肌能量利用和能量生产能力的协调反应。然而，在冬眠心肌中，观察到了一些形态和功能的变化，这些变化可以识别完全血运重建可能不会导致收缩正常化的区域。事实上，冬眠组织中代谢异常最严重的心肌区域表现出最长的恢复延迟。在最新一期中，Page等人12证明了冬眠过程与线粒体蛋白表达的改变有关。在猪冬眠模型中使用2D凝胶内差示电泳法和基质辅助激光解吸电离飞行时间质谱仪，他们发现与电子传输链相关的关键线粒体蛋白质减少。通过丙酮酸脱氢酶复合体、细胞色素c氧化酶和柠檬酸合成酶活性降低的测量，证明了蛋白质表达降低的功能重要性。冠状动脉缩窄术后5个月线粒体蛋白和收缩功能的平行下降表明，电子传递蛋白的“下调”与氧耗的减少有关。事实上，ATPase的减少与冬眠心肌心内膜下血流量的减少有关。此外，还观察到了几种胞浆蛋白的“上调”，包括抗氧化酶超氧化物歧化酶1，突出了潜在的作用。
Winter hibernation carries the promise of rejuvenation in the spring. In a similar fashion, myocardial “hibernation” describes a clinical phenomenon in which patients with ischemic left ventricular dysfunction demonstrate improved cardiac function following bypass surgery. 1 The signature of myocardial hibernation is decreased blood flow with preserved glucose uptake, as demonstrated by positron emission tomography imaging, and identifies individuals with ischemic cardiomyopathy who may benefit from revascularization. 2 In experimental models of hibernating myocardium, oxygen consumption is reduced in the absence of active ischemia. 3, 4 This implies that hibernation is a coordinated response to balance myocardial energy utilization with energy production capacity. 5 However, within hibernating myocardium, several morphological and functional changes have been observed that can identify regions in which complete revascularization may not result in normalization of contraction. 6–10 In fact, those myocardial regions with the greatest metabolic abnormalities in the hibernating tissue demonstrate the longest delay in recovery. 11In the current issue, Page et al12 demonstrate that the process of hibernation is associated with altered expression of mitochondrial proteins. Using 2D differential-in-gel electrophoresis and matrix-assisted laser desorption ionization timeof-flight mass spectrometry in a swine model of hibernation, they have found that key mitochondrial proteins associated with the electron transport chain are reduced. The functional importance of the decreased protein expression is documented by reduced activity measurements of the pyruvate dehydrogenase complex, cytochrome c oxidase, and citrate synthase. The parallel reductions in mitochondrial proteins and contractile function 5 months after placement of the coronary artery constrictor suggest that the “downregulation” of electron transport proteins is related to the reduced oxygen consumption. In fact, the reductions in ATPase correlate with the reduction in subendocardial blood flows in the hibernating myocardium. In addition,“upregulation” of several cytosolic proteins has been observed, including the antioxidant enzyme superoxide dismutase 1, highlighting a potential role
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影响因子：
37.8
作者：
Lim, HJ;Fallavollita, JA;Canty, JM
通讯作者：
Canty, JM
影响因子：
37.8
作者：
Zhang,J;McDonald,KM
通讯作者：
McDonald,KM
对心肌缺血的反应是一个调节过程。
影响因子：
37.8
作者：
Bristow,JD;Arai,AE;Anselone,CG;Pantely,GA
通讯作者：
Pantely,GA
影响因子：
5
作者：
McFalls, Edward O.;Sluiter, Wim;Duncker, Dirk J.
通讯作者：
Duncker, Dirk J.
影响因子：
4.1
作者：
Nadtochiy, SM;Tompkins, AJ;Brookes, PS
通讯作者：
Brookes, PS