Impact of Pancreatectomy on Long-Term Patient-Reported Symptoms and Quality of Life in Recurrence-Free Survivors of Pancreatic and Periampullary Neoplasms
Impact of Pancreatectomy on Long-Term Patient-Reported Symptoms and Quality of Life in Recurrence-Free Survivors of Pancreatic and Periampullary Neoplasms
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DOI：
10.1002/jso.24499
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发表时间：
2017-02-01
影响因子：
2.5
通讯作者：
Katz, Matthew H. G.
中科院分区：
文献类型：
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作者：
Cloyd, Jordan M.;Cao, Hop S. Tran;Katz, Matthew H. G.
背景资料：长期的患者报告的症状和生活质量（QOL）是重要的结果指标癌症手术后，但已经很少描述的患者谁曾接受pancreatectomy.Methods：Weconducted一个横断面调查复发的胰腺导管腺癌，壶腹周围癌，胰腺神经内分泌肿瘤的幸存者谁曾接受过胰腺切除术。使用癌症治疗功能评估-肝胆问卷测量QOL和症状负担，使用医院焦虑和抑郁量表测量心理社会困扰。在接受调查的331名合格患者中，217名（66%）参与了中位数为53.3（范围，7.6-214.8）个月后胰腺切除术（PD，n = 165）或远端胰腺切除术（DP，n = 52）。在所有患者中，总体生活质量评分是有利的，并受到种族，组织学和手术类型的影响。报告的最常见的显著症状是疲劳（82%），背痛（32%）和消化困难（31%）。总体而言，PD幸存者的生活质量更好，焦虑/抑郁水平更低，腹泻水平更高，食欲、便秘、疲劳、焦虑和抑郁改善（P
Background: Long term patient-reported symptoms and quality of life (QOL) are important outcome metrics following cancer operations, but have been poorly described in patients who have previously undergone pancreatectomy.Methods: Weconducted a cross-sectional survey of recurrence-free survivors of pancreatic ductal adenocarcinoma, periampullary carcinomas, and pancreatic neuroendocrine tumors who had undergone prior pancreatectomy. QOL and symptom burden were measured using the Functional Assessment of Cancer Therapy-Hepatobiliary Questionnaire, and psychosocial distress was measured using the Hospital Anxiety and Depression Scale.Results: Of 331 eligible patients surveyed, 217 (66%) participated at a median of 53.3 (range, 7.6-214.8) months following pancreatoduodenectomy (PD, n = 165) or distal pancreatectomy (DP, n = 52). Among all patients, overall QOL scores were favorable and influenced by race, histology, and type of surgery. The most common significant symptoms reported were fatigue (82%), back pain (32%), and difficulty with digestion (31%). In general, PD survivors reported better QOL, lower levels of anxiety/depression, greater levels of diarrhea, and improved appetite, constipation, fatigue, anxiety, and depression (P